TRENDS IN THE CONTENT AND USE OF ORAL-CONTRACEPTIVES IN THE UNITED-STATES, 1964-88
TRENDS IN THE CONTENT AND USE OF ORAL-CONTRACEPTIVES IN THE UNITED-STATES, 1964-88
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DOI：
10.2105/ajph.81.1.90
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发表时间：
1991-01-01
影响因子：
12.7
通讯作者：
STADEL, BV
中科院分区：
文献类型：
--
作者：
GERSTMAN, BB;GROSS, TP;STADEL, BV
使用药品营销和医生调查数据来研究 1964 年至 1988 年间美国口服避孕药的使用和激素含量趋势。口服避孕药的零售处方在 1973 年达到峰值，约为 6800 万张，自 1981 年以来一直保持在 5000 万至 6000 万张之间。尽管处方数量相对一致，但医生“提到”口服避孕药的次数增加了约75%。 这种增加可能反映了对女性口服避孕药的更密切监测。 多相制剂的使用量稳步上升，1988 年占口服避孕药处方的 37%。所有类型制剂中的平均雌激素和孕激素剂量都在稳步下降。 制剂中使用的雌激素和孕激素类型的变化与剂量的下降同时发生。 过去看到的年龄和使用高剂量制剂之间的关联在 1988 年不再明显。数据表明，当今广泛使用的口服避孕药制剂的激素含量与过去有所不同，当时大多数解决与口服避孕药使用相关风险的主要研究已经完成。 因此，需要确定与这些新配方相关的风险和长期影响。
Drug marketing and physician survey data were used to examine trends in the use and hormonal content of oral contraceptives in the United States between 1964 and 1988. Retail prescriptions for oral contraceptives peaked at approximately 68 million in 1973 and have remained between 50 million and 60 million since 1981. Despite this relative consistency in the number of prescriptions, physician "mentions" of oral contraceptives have increased by approximately 75 percent. This increase may reflect closer monitoring of women on oral contraceptives. Use of multiphasic formulations has steadily risen, accounting for 37 percent of the oral contraceptive prescriptions in 1988. Mean estrogen and progestin doses in all types of formulations have steadily declined. A change in the type of estrogen and progestin used in preparations has coincided with this decline in dose. The association between age and use of high-dose formulations seen in the past was no longer evident in 1988. The data demonstrate that oral contraceptive formulations in wide use today differ in hormone content from those of the past, when most of the major studies addressing the risks associated with oral contraceptive use were completed. There is therefore a need to determine the risks and long-term effects associated with these newer formulations.