EFFECTS OF EXOPOLYSACCHARIDE PRODUCTION BY VIRIDANS STREPTOCOCCI ON PENICILLIN THERAPY OF EXPERIMENTAL ENDOCARDITIS
EFFECTS OF EXOPOLYSACCHARIDE PRODUCTION BY VIRIDANS STREPTOCOCCI ON PENICILLIN THERAPY OF EXPERIMENTAL ENDOCARDITIS
复制标题
DOI：
10.1093/infdis/151.1.153
复制
发表时间：
1985-01-01
影响因子：
6.4
通讯作者：
MILLS, J
中科院分区：
文献类型：
--
作者：
PULLIAM, L;DALL, L;MILLS, J
在患有实验性主动脉瓣心内膜炎的兔子中研究了草绿色链球菌产生的胞外多糖对青霉素治疗心内膜炎的影响。动物首先感染青霉素敏感的链球菌，已知该链球菌会在心脏赘生物中产生不同量的胞外多糖。感染后 1-2 天开始用普鲁卡因青霉素治疗，每 12 小时 300,000 U。治疗 5 天后，感染血链球菌 II 和 S. morbillorum 的动物（两者均具有旺盛的胞外多糖产生能力）继续感染植被，而感染 S. salivarius 和不同的血链球菌 II（两者均缺乏胞外多糖产生）的动物植被不育。这些发现表明，未能从植被中根除链球菌与胞外多糖的产生有关，并且这种特性对于确定治疗结果可能很重要。
The influence of exopolysaccharide production by viridans streptococci on penicillin therapy of endocarditis was studied in rabbits with experimental aortic-valve endocarditis. Animals were first infected with penicillin-susceptible streptococci known to produce varying amounts of exopolysaccharide in cardiac vegetations. Treatment with procaine penicillin, 300,000 U every 12 h, was begun 1-2 days after infection. After 5 days of therapy, animals infected with Streptococcus sanguis II and S. morbillorum, both vigorous exopolysaccharide producers, continued to have infected vegetations, while animals infected with S. salivarius and a different S. sanguis II, both deficient in exopolysaccharide production, had sterile vegetations. These findings indicate that failure to eradicate streptococci from vegetations correlates with exopolysaccharide production and that this property may be important in determining outcome of therapy.