The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues
The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues
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DOI：
10.1002/pro.5560050720
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发表时间：
1996-07-01
期刊：
影响因子：
8
通讯作者：
Schultz, J
中科院分区：
文献类型：
--
作者：
Bork, P;Brown, NP;Schultz, J
对真核蛋白丝氨酸/苏氨酸磷酸酶2C（PP2C）家族的各种成员的彻底序列分析揭示了11个基序的保护。这些基序可以在许多其他序列中鉴定出来，以避免被预测包含功能活性的PP2C结构域的真菌腺苷酸环化酶以及包括Spoiie在内的原核丝氨酸丝氨酸/苏氨酸磷酸酶的家族。对所有蛋白质的系统发育分析表明，可以推断出相当数量的同工酶。
A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, in eluding fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.