Unrelated umbilical cord blood transplantation and immune reconstitution.
Unrelated umbilical cord blood transplantation and immune reconstitution.
复制标题
DOI：
10.1053/j.seminhematol.2009.10.009
复制
发表时间：
2010-01
影响因子：
3.6
通讯作者：
Cairo MS
中科院分区：
文献类型：
--
作者：
Szabolcs P;Cairo MS
This review will highlight the unique features of immune reconstitution following unrelated cord blood transplantation (UCBT) that lead to heightened risk of infection related mortality (IRM) in the early post UCBT period. There is no evidence that the innate immunity is uniquely compromised after UCBT, however, the development of antigen-specific cellular immunity is affected by numerical and qualitative deficits in the early post-UCBT period, primarily within the first 100 days. Nevertherless, beyond the first few months after UCBT there is no evidence for reduced graft-versus-leukemia (GVL) or anti-viral immunity compared to other hematopoietic cell therapy (HCT) modalities. Immune reconstitution is addressed in both myeloablative and the non-myeloablative settings. Novel cellular therapies that are about to enter the clinical setting in the form of natural killer (NK) cell and T cell therapies in the form of donor lymphocyte infusion (DLI) are also discussed.
登录
查看更多内容
影响因子：
20.3
作者：
Godfrey, WR;Spoden, DJ;Porter, SB
通讯作者：
Porter, SB
影响因子：
158.5
作者：
Gluckman, E;Rocha, V;Chastang, C
通讯作者：
Chastang, C
影响因子：
4.3
作者：
Barker, JN;Hough, RE;Wagner, JE
通讯作者：
Wagner, JE
影响因子：
2.6
作者：
Frias, Ana M.;Porada, Christopher D.;Almeida-Porada, Garca
通讯作者：
Almeida-Porada, Garca
供体型CD4（+）CD25（+）调节性T细胞在同种异体骨髓移植后抑制致命的急性移植物抗宿主疾病。
影响因子：
15.3
作者：
Hoffmann, Petra;Ermann, Joerg;Edinger, Matthias;Fathman, C Garrison;Strober, Samuel
通讯作者：
Strober, Samuel