Clinicopathological features of gastric cancer cases and aberrantly expressed recoverin
Clinicopathological features of gastric cancer cases and aberrantly expressed recoverin
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DOI：
10.1620/tjem.202.213
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发表时间：
2004-03-01
影响因子：
2.2
通讯作者：
Nakazawa, M
中科院分区：
文献类型：
--
作者：
Ohguro, H;Odagiri, H;Nakazawa, M
癌症相关性视网膜病变（CAR）是副肿瘤综合征的眼部表现，其中针对视网膜特异性钙结合蛋白recoverin和在肿瘤细胞中异常表达的其他视网膜抗原的免疫反应导致视网膜感光细胞变性。最近我们报道了在胃癌、肺癌等多种肿瘤的50%以上的肿瘤细胞及其细胞系中发现了recoverin的异常表达。为了阐明癌细胞中异常表达的恢复素的临床病理学意义，我们使用抗人恢复素的单克隆抗体进行免疫细胞化学分析。在18名不同临床分期（I-IV）的胃癌患者中，6名患者的肿瘤细胞中发现了recoverin的异常表达（2名IA期患者中有2名，1名1B期患者中有1名，3名II期患者中有2名，0名7名IIIA期患者，0名I期IIIB患者，1名IV期患者）。目前的数据与先前的观察结果部分一致，即表达恢复蛋白的癌细胞诱导肿瘤免疫并为CAR患者的原发性癌症提供有利的预后。(C)东北大学医学出版社.
Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions toward recoverin, a retina-specific calcium binding protein, and other retinal antigens aberrantly expressed in tumor cells lead to the degeneration of retinal photoreceptor cells. Recently we reported that aberrant expression of recoverin was identified in more than 50% of tumor cells and their cell lines from several kinds of cancers, including gastric cancer, lung carcinoma, and other cancers. To elucidate the clinicopathological significance of aberrantly expressed recoverin in cancer cells, we performed immunocytochemical analysis using a monoclonal antibody against human recoverin. Within 18 patients with different clinical stages (I-IV) of castric cancer, the aberrant expression of recoverin in tumor cells was recognized in 6 out of 18 patients (2 out of 2 stage IA, 1 out of 1 stage 1B, 2 out of 3 stage II, 0 out of 7 stage IIIA, 0 out of I stage IIIB, and I out 4 stage IV). The present data are consistent in part with the previous observations that recoverin-expressing cancer cells induced tumor immunity and provide a favorable prognosis for primary cancer in CAR patients. (C) 2004 Tohoku University Medical Press.