CHLORPROMAZINE INHIBITS PHAGOCYTOSIS AND EXOCYTOSIS IN RABBIT POLYMORPHONUCLEAR LEUKOCYTES
CHLORPROMAZINE INHIBITS PHAGOCYTOSIS AND EXOCYTOSIS IN RABBIT POLYMORPHONUCLEAR LEUKOCYTES
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DOI：
10.1016/0006-2952(79)90287-9
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发表时间：
1979-01-01
影响因子：
5.8
通讯作者：
ELFERINK, JGR
中科院分区：
文献类型：
--
作者：
ELFERINK, JGR
氯丙嗪可抑制多形核白细胞对酵母多糖颗粒的吞噬作用和伴随的胞吐作用释放溶酶体酶。细胞松弛素B防止颗粒摄取，但不释放酶;二价阳离子离子载体A 23187诱导酶释放酵母聚糖的情况下，如果存在Ca 2+。在这两种情况下，酶的释放被氯丙嗪抑制，并证明氯丙嗪对胞吐作用的影响独立于其对吞噬作用的影响。结果进行了讨论，在有关的作用中的Ca 2+的胞吐和氯丙嗪对膜性能的影响。
Phagocytosis of zymosan particles and the concomitant release of lysosomal enzymes by exocytosis in polymorphonuclear leukocytes is inhibited by chlorpromazine. Cytochalasin B prevents particle uptake but not enzyme release; the divalent cation ionophore A 23187 induces enzyme release in the absence of zymosan if Ca2+ is present. In both cases enzyme release is inhibited by chlorpromazine and demonstrates an effect of chlorpromazine on exocytosis independent of its effect on phagocytosis. The results are discussed in relation to the role of Ca2 in exocytosis and the effect of chlorpromazine on membrane properties.