Leukocyte-mediated endothelial cell injury and death in the diabetic retina
Leukocyte-mediated endothelial cell injury and death in the diabetic retina
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DOI：
10.1016/s0002-9440(10)63952-1
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发表时间：
2001-01-01
影响因子：
6
通讯作者：
Adamis, AP
中科院分区：
文献类型：
--
作者：
Joussen, AM;Murata, T;Adamis, AP
内皮细胞死亡是糖尿病视网膜病变的一个标志。它的发生是形成无细胞(失活)毛细血管所必需的，这些病变通过现在无法支持血液而产生不可逆转的视网膜缺血。糖尿病视网膜内皮细胞损伤和死亡的机制在很大程度上仍不清楚。目前的研究表明，在链脲佐菌素诱导的实验性糖尿病大鼠1周内，黏附的白细胞在时间和空间上与视网膜内皮细胞的损伤和死亡有关。此外，基于抗体的细胞间黏附分子-1和CD18的中和被证明可以防止白细胞黏附和视网膜内皮细胞的损伤和死亡。这些数据强调了粘附性白细胞在糖尿病视网膜病变发病机制中的中心和因果作用。他们还强调了基于抗细胞间黏附分子1和抗CD18的疗法在治疗糖尿病视网膜病变方面的潜在效用，糖尿病视网膜病变是一种新发现的炎症性疾病。
Endothelial cell death is a hallmark of diabetic retinopathy. Its occurrence is required for the formation of acellular (devitalized) capillaries, lesions that produce irreversible retinal ischemia through their inability to support blood now. The mechanisms underlying diabetic retinal endothelial cell injury and death remain largely unknown. The current study demonstrates that adherent leukocytes are temporally and spatially associated with retinal endothelial cell injury and death within 1 week of streptozotocin-induced experimental diabetes in rats. Moreover, the antibody-based neutralization of intercellular adhesion molecule-1 and CD18 is shown to prevent both leukocyte adhesion and retinal endothelial cell injury and death. These data highlight the central and causal role of adherent leukocytes in the pathogenesis of diabetic retinopathy. They also underscore the potential utility of anti-intercellular adhesion molecule1- and anti-CD18-based therapies in the treatment of diabetic retinopathy, a newly recognized inflammatory disease.