Development of a Biomaterial from Naturally Occurring Chloroapatite Mineral for Biomedical Applications
Development of a Biomaterial from Naturally Occurring Chloroapatite Mineral for Biomedical Applications
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开发用于生物医学应用的天然氯磷灰石矿物生物材料
DOI：
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发表时间：
2018
期刊：
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通讯作者：
H. Pitawala
中科院分区：
文献类型：
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作者：
H. K. G. K. D. K. Hapuhinna;Rajitha D. Gunaratne;H. Pitawala
羟基磷灰石是一种生物陶瓷，由于其结构与哺乳动物骨骼和牙齿的矿物相相似，可用于骨科和牙科。在这项研究中，它是合成的，化学改变天然Eppawala氯磷灰石矿物作为增值产品。以稀硝酸、乙醇和氢氧化钙为原料，采用溶胶-凝胶法和固相烧结法在不同条件下合成了产物。采用X射线荧光（XRF）、X射线粉末衍射（XRD）、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、热重分析（TGA）和差示扫描量热法（DSC）对合成的Eppawala羟基磷灰石粉末进行了表征，以了解其组成、结晶度、官能团的存在、键合类型、表面形貌、微观结构特征，以及热依赖性和稳定性。XRD结果反映了羟基磷灰石的六方晶体结构的形成。通过对合成的羟基磷灰石粉末的X射线荧光光谱和扫描电镜分析，讨论了产物的元素组成和微观结构特征。TGA和DSC结果表明，合成产物具有较高的热稳定性和良好的材料稳定性。此外，FTIR光谱结果证实了羟基磷灰石通过羟基基团的存在形成羟基磷灰石。这些结果与包括人骨在内的哺乳动物骨的FTIR结果一致。该研究得出结论认为，在斯里兰卡有可能使用市售的Eppawala氯磷灰石生产羟基磷灰石。关键词-牙科，eppawala氯磷灰石，羟基磷灰石，骨科。
Hydroxyapatite is a bioceramic which can be used for applications in orthopedics and dentistry due to its structural similarity with the mineral phase of mammalian bones and teeth. In this study, it was synthesized, chemically changing natural Eppawala chloroapatite mineral as a value-added product. Sol-gel approach and solid state sintering were used to synthesize products using diluted nitric acid, ethanol and calcium hydroxide under different conditions. Synthesized Eppawala hydroxyapatite powder was characterized using X-ray Fluorescence (XRF), X-ray Powder Diffraction (XRD), Fourier-transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) in order to find out its composition, crystallinity, presence of functional groups, bonding type, surface morphology, microstructural features, and thermal dependence and stability, respectively. The XRD results reflected the formation of a hexagonal crystal structure of hydroxyapatite. Elementary composition and microstructural features of products were discussed based on the XRF and SEM results of the synthesized hydroxyapatite powder. TGA and DSC results of synthesized products showed high thermal stability and good material stability in nature. Also, FTIR spectroscopy results confirmed the formation of hydroxyapatite from apatite via the presence of hydroxyl groups. Those results coincided with the FTIR results of mammalian bones including human bones. The study concludes that there is a possibility of producing hydroxyapatite using commercially available Eppawala chloroapatite in Sri Lanka. Keywords–Dentistry, eppawala chloroapatite, hydroxyapatite, orthopedics.