The Impact of Vitamin D Status on Periodontal Surgery Outcomes
The Impact of Vitamin D Status on Periodontal Surgery Outcomes
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DOI：
10.1177/0022034511407771
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发表时间：
2011-08-01
影响因子：
7.6
通讯作者：
McCauley, L. K.
中科院分区：
文献类型：
--
作者：
Bashutski, J. D.;Eber, R. M.;McCauley, L. K.
维生素D调节钙和免疫功能。虽然维生素D缺乏与牙周炎有关，但关于其对伤口愈合和牙周手术结果的影响的信息很少。这项纵向临床试验评估了维生素d充足和缺乏个体牙周手术和特立帕肽治疗的结果。40例严重慢性牙周炎患者接受牙周手术，每日补充钙和维生素D，并自行服用特立帕肽或安慰剂6周，以配合骨愈合时间。在基线、术后6周和术后6周评估血清25(OH) D。临床和影像学结果评估超过1年。基线维生素D缺乏的安慰剂患者[血清25(OH) D， 16-19 ng/mL]的临床附着损失（CAL）增加（-0.43 mm vs. 0.92 mm, p < 0.01）和探测深度（PPD）减少（0.43 mm vs. 1.83 mm, p < 0.01）明显少于维生素D充足的个体。维生素D水平对特立帕肽患者1年的CAL和PPD改善没有显著影响，但特立帕肽治疗的维生素D充足者比维生素D缺乏者的下骨缺损分辨率更高（2.05 mm对0.87 mm, p = 0.03）。牙周手术时缺乏维生素D会对治疗结果产生长达1年的负面影响。对这些数据的分析表明，维生素D状态可能对术后愈合至关重要。（ClinicalTrials.gov号码：CT00277706）
Vitamin D regulates calcium and immune function. While vitamin D deficiency has been associated with periodontitis, little information exists regarding its effect on wound healing and periodontal surgery outcomes. This longitudinal clinical trial assessed outcomes of periodontal surgery and teriparatide administration in vitamin-D-sufficient and -insufficient individuals. Forty individuals with severe chronic periodontitis received periodontal surgery, daily calcium and vitamin D supplements, and self-administered teriparatide or placebo for 6 wks to correspond with osseous healing time. Serum 25(OH) D was evaluated at baseline, 6 wks, and 6 mos post-surgery. Clinical and radiographic outcomes were evaluated over 1 yr. Placebo patients with baseline vitamin D deficiency [ serum 25(OH) D, 16-19 ng/mL] had significantly less clinical attachment loss (CAL) gain (-0.43 mm vs. 0.92 mm, p < 0.01) and probing depth (PPD) reduction (0.43 mm vs. 1.83 mm, p < 0.01) than vitamin-D-sufficient individuals. Vitamin D levels had no significant impact on CAL and PPD improvements in teriparatide patients at 1 yr, but infrabony defect resolution was greater in teriparatide-treated vitamin-D-sufficient vs. -deficient individuals (2.05 mm vs. 0.87 mm, p = 0.03). Vitamin D deficiency at the time of periodontal surgery negatively affects treatment outcomes for up to 1 yr. Analysis of these data suggests that vitamin D status may be critical for post-surgical healing. (ClinicalTrials.gov number, CT00277706)