Smoking cessation and subsequent risk of cancer: A pooled analysis of eight population-based cohort studies in Japan
Smoking cessation and subsequent risk of cancer: A pooled analysis of eight population-based cohort studies in Japan
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DOI：
10.1016/j.canep.2017.10.013
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发表时间：
2017-12-01
影响因子：
2.6
通讯作者：
Sasazuki, Shizuka
中科院分区：
文献类型：
--
作者：
Saito, Eiko;Inoue, Manami;Sasazuki, Shizuka
背景：虽然东亚是世界上最大的烟草流行地区之一，但只有少数来自亚洲的前瞻性研究调查了吸烟和戒烟对癌症的影响。方法：我们分析了日本8项基于人群的前瞻性队列研究的汇总数据，以评估戒烟对总癌症和吸烟相关癌症风险的影响。结果：在调整了潜在的混杂因素后，在基线前戒烟21年的男性患癌症的风险降至与从不吸烟者相同的总癌症风险水平(从未吸烟者：参考；有吸烟史的吸烟者；=戒烟21年：HR，1.01；95%可信区间：0.91，1.11)。即使是重度吸烟者(超过20包年)也报告总癌症风险降低(从不吸烟者：参考；戒烟21年前吸烟者：HR，1.06；95%CI：0.92，1.23)。在女性中，在基线前戒烟11年后，完全患癌症的风险与从不吸烟的人没有差异(从未吸烟者：参考；戒烟后11年有吸烟史：HR，0.96；95%CI：0.74，1.23)。结论：我们的研究表明，较长的戒烟时间可能会降低男性和女性的癌症风险，即使是重度吸烟者(超过20包年)也能从戒烟中受益。
Background: Although East Asia is one of the largest tobacco-epidemic regions in the world, only a few prospective studies from Asia have investigated the impact of smoking and cessation of smoking on cancer. We aimed to assess the effect of cessation of smoking on the risk of cancer using eight population-based cohort studies in Japan.Methods: We analyzed pooled data from eight population-based prospective cohort studies in Japan with more than 320,000 participants to assess the effect of smoking cessation on the risk of total cancers and smoking-related cancers.Results: After adjustment for potential confounders, cancer risks in men with > 21 years of smoking cessation before baseline were found to decrease to the same level as never smokers for total cancer (never smokers: reference; former smokers with >= 21 years since smoking cessation: HR, 1.01; 95%CI: 0.91, 1.11). Even men who are heavy smokers (more than 20 pack-years) reported a reduced risk of total cancer (never smokers: reference; former smokers with >= 21 years since smoking cessation: HR, 1.06; 95%CI: 0.92, 1.23). In women, the risk of total cancer did not differ from that of never smokers after 11 years of smoking cessation before baseline (never smokers: reference; former smokers with >= 11 years since smoking cessation: HR, 0.96; 95%CI: 0.74, 1.23).Conclusions: Our study suggests that longer duration of smoking cessation may attenuate the risk of cancer in both men and women, and that even heavy smokers (more than 20 pack-years) were found to benefit from quitting smoking.