Simple Hydrothermal New Synthesis of Magnetic Nano Octahedron: Application to Hyperthermia Cancer Cell Killing
Simple Hydrothermal New Synthesis of Magnetic Nano Octahedron: Application to Hyperthermia Cancer Cell Killing
复制标题
磁性纳米八面体的简单水热新合成：在高温杀死癌细胞中的应用
DOI：
10.1139/v2012-046
复制
发表时间：
2012
影响因子：
1.1
通讯作者：
Md. Shariful Islam
中科院分区：
文献类型：
--
作者：
Md. Abdulla-Al-Mamun;Yoshihumi Kusumoto;Md. Shariful Islam
以硝酸铁（Fe（NO3）3·9 H2O）为原料，在不同碱浓度的水-乙醇混合溶剂中，通过碱热分解法成功制备了无表面活性剂的磁性纳米八面体。高分辨率扫描电子显微镜（SEM）照片表明，八面体结构的磁性纳米粒子在10 mol/L的碱性浓度的形成。探讨了磁性纳米八面体的可能合成机理。研究了交变磁场诱导高温对癌细胞的杀伤作用。10 mol/L碱合成的纳米八面体的最大高温癌细胞杀伤率（~100%），而2 mol/L碱的最大高温癌细胞杀伤率为~ 40%。
Surfactant-free magnetic nano-octahedrons were successfully synthesized by the alkaline hydrothermal decomposition of ferric nitrate salt (Fe(NO3)3·9H2O) in a water–ethanol mixed solvent with a variety of alkaline concentrations. High-resolution scanning electron microscope (SEM) pictures demonstrated the formation of octahedron-structured magnetic nanoparticles at a 10 mol/L alkaline concentration. A possible synthesis mechanism of the magnetic nano-octahedron was discussed. An alternating current magnetic field to induce hyperthermia cancer cell killing was investigated. Maximum hyperthermia cancer cell killing (~100%) was found with 10 mol/L alkaline-synthesized nano-octahedrons, whereas that with 2 mol/L alkaline gave ~40%.