TRPA1 Role in Inflammatory Disorders: What Is Known So Far?
TRPA1 Role in Inflammatory Disorders: What Is Known So Far?
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DOI：
10.3390/ijms23094529
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发表时间：
2022-04-20
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
瞬时受体电位锚蛋白1（TRPA1）是TRP通道超家族的成员，主要位于三叉神经、迷走神经和背根神经节的初级感觉神经元亚群中，其激活介导神经源性炎症反应。TRPA 1在常驻组织细胞、炎症细胞和免疫细胞中的表达，通过间接调节大量细胞内途径，协调一系列细胞过程，例如细胞因子产生、细胞分化和细胞毒性。因此，TRPA1通路已被提出作为一种保护机制，以检测和应对各种病理条件下的有害物质，包括几种炎性疾病。特别关注TRPA1对炎症和免疫反应从早期防御反应向慢性病理状态转变的贡献。从这个角度来看，TRPA 1拮抗剂可被视为治疗炎症性疾病的有益工具。
The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, is primarily localized in a subpopulation of primary sensory neurons of the trigeminal, vagal, and dorsal root ganglia, where its activation mediates neurogenic inflammatory responses. TRPA1 expression in resident tissue cells, inflammatory, and immune cells, through the indirect modulation of a large series of intracellular pathways, orchestrates a range of cellular processes, such as cytokine production, cell differentiation, and cytotoxicity. Therefore, the TRPA1 pathway has been proposed as a protective mechanism to detect and respond to harmful agents in various pathological conditions, including several inflammatory diseases. Specific attention has been paid to TRPA1 contribution to the transition of inflammation and immune responses from an early defensive response to a chronic pathological condition. In this view, TRPA1 antagonists may be regarded as beneficial tools for the treatment of inflammatory conditions.
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DOI：
10.1523/jneurosci.5369-07.2008
发表时间：
2008-03-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andersson DA;Gentry C;Moss S;Bevan S
通讯作者：
Bevan S
影响因子：
5.6
作者：
Batai, Istvan Z.;Sar, Cecilia Papaine;Pinter, Erika
通讯作者：
Pinter, Erika
影响因子：
3.3
作者：
Bolcskei, Kata;Kriszta, Gabor;Pinter, Erika
通讯作者：
Pinter, Erika
影响因子：
5.1
作者：
Buech, Thomas Robert Heinrich;Schaefer, Eva Anna Maria;Schmidt, Annette
通讯作者：
Schmidt, Annette
影响因子：
15.9
作者：
Bessac, Bret F.;Sivula, Michael;Jordt, Sven-Eric
通讯作者：
Jordt, Sven-Eric