Congenital eye defects in the mouse. II. The influence of litter size, litter spacing, and suckling of offspring on risk of eye defects in C57BL mice.
Congenital eye defects in the mouse. II. The influence of litter size, litter spacing, and suckling of offspring on risk of eye defects in C57BL mice.
复制标题
小鼠先天性眼睛缺陷。
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
J. Spiggle
中科院分区：
文献类型：
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作者：
L. Pierro;J. Spiggle
在C57 BL小鼠中自发地发生眼睛缺陷，包括角膜容量、小眼球、白内障和无眼球。本报告中描述的亚株C57 BL/10 ChPr的育种实验表明，在第一窝中包含眼缺陷动物的概率受窝间距、窝仔数和后代哺乳的影响。第二和第三窝可能包括眼睛缺陷的后代，因为第一窝，如果他们导致交配发生后断奶的前一窝或如果母亲被阻止从她的前一窝哺乳。如果妊娠期与前一窝幼崽的哺乳期重叠，则产生的窝仔包含较少的后代，并且不太可能包括眼睛缺陷的动物。窝仔数减少似乎是由于着床前胚胎丢失所致。妊娠和哺乳的年轻人之间的重叠，在用于股票维护交配的患病率，导致一个明显的下降，随着增加窝排名的频率，包括后代的眼睛缺陷。
Eye defects including corneal capacity, microphthalmia, cataract, and anophthalmia occur spontaneously in C57BL mice. Breeding experiments with substrain C57BL/10ChPr described in the present report indicated that the probability of inclusion of animals with eye defects in litters subsequent to the first is influenced by litter spacing, litter size, and suckling of offspring. Second and third litters were as likely to include progeny with eye defects as were first litters if they resulted from matings taking place after weaning of the previous litter or if the mother was prevented from suckling her previous litter. If the gestation period overlapped with suckling of young from a previous litter the resulting litter contained fewer offspring and animals with eye defects were less likely to be included. Reduction in litter size appeared to result from embryonic losses prior to the time of implantation. The prevalence of overlap between gestation and suckling of young, in matings used for stock maintenance, led to an apparent decline with increasing litter rank in the frequency of litters that included progeny with eye defects.