EFFECT OF STIMULANT-DRUGS, DEXTROAMPHETAMINE AND METHYLPHENIDATE, ON SECRETION OF GROWTH-HORMONE IN HYPERACTIVE-CHILDREN
EFFECT OF STIMULANT-DRUGS, DEXTROAMPHETAMINE AND METHYLPHENIDATE, ON SECRETION OF GROWTH-HORMONE IN HYPERACTIVE-CHILDREN
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DOI：
10.1016/s0022-3476(77)80788-9
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发表时间：
1977-01-01
影响因子：
5.1
通讯作者：
THORSEN, T
中科院分区：
文献类型：
--
作者：
AARSKOG, D;FEVANG, FO;THORSEN, T
本文比较了L多巴(12 5~5 0 0 mg)、右旋苯丙胺(15 Mg)和哌醋甲酯(2 0 Mg)对20例多动儿生长激素分泌的刺激作用。3种兴奋剂均导致服药后60min血清GH浓度最高，各时间点GH均值差异无统计学意义。其中7名儿童在6-8个月后复测L-多巴和右旋苯丙胺。使用哌醋甲酯治疗。治疗后，GH有升高的趋势，对右旋苯丙胺的反应延迟和/或自相矛盾。这些发现表明右旋苯丙胺和哌醋甲酯对生长激素的稳态有急性和可能的长期影响。这些药物对儿童生长发育可能产生的长期不良影响表明，在广泛使用这些药物时需要谨慎。
The stimulant effect of L-dopa (125-500 mg) was compared to dextroamphetamine and methylphenidate, 15 and 20 mg, respectively, on growth hormone [GH] secretion in 20 hyperactive children. All 3 stimulants were responsible for peak GH concentration in serum at 60 min after drug ingestion; there was no significant difference between the mean GH level at any time of sampling. Seven of the children were retested with L-dopa and dextroamphetamine after 6-8 mo. of treatment with methylphenidate. After treatment, there was a tendency to higher zero time levels of GH, and to delayed and/or paradoxical response to dextroamphetamine. The findgings indicate an acute and a probable long-term effect of dextroamphetamine and methylphenidate on the homeostasis of GH. The possible long-term adverse effects of these drugs on the growth of children indicates the need for caution in the widespread use of these agents.