EFFECT OF 3,3'-DI-IODOTHYRONINE AND 3,5-DI-IODOTHYRONINE ON RAT-LIVER MITOCHONDRIA
EFFECT OF 3,3'-DI-IODOTHYRONINE AND 3,5-DI-IODOTHYRONINE ON RAT-LIVER MITOCHONDRIA
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DOI：
10.1677/joe.0.1360059
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发表时间：
1993-01-01
影响因子：
4
通讯作者：
GOGLIA, F
中科院分区：
文献类型：
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作者：
LANNI, A;MORENO, M;GOGLIA, F
在本研究中，我们报告了3，3 '，5-三碘甲状腺原氨酸（T_3）以及两种碘甲状腺原氨酸（3，5-二碘甲状腺原氨酸（3，5-T2）和3，3 '-二碘甲状腺原氨酸（3，3'-T2））显著影响大鼠肝脏线粒体活性。（以细胞色素氧化酶活性/g湿组织计）与正常大鼠相比，甲状腺功能减退大鼠的（21%，P>0.01），T3和两种碘甲腺原氨酸治疗后恢复正常。在线粒体水平，T3刺激呼吸活性（状态4和状态3），并没有影响细胞色素氧化酶的活性。另一方面，甲状腺功能减退动物经3，3 '-T2或3，5-T2处理后，线粒体呼吸速率和细胞色素氧化酶比活性均显著增加（分别约50%和40%）。两种碘甲腺原氨酸的作用在注射后1小时迅速而明显。甲状腺功能低下大鼠肝线粒体蛋白含量明显降低（9.6mg/g肝，正常对照组为14.1mg/g肝，P
In the present study we report that 3,3',5-tri-iodothyronine (T3) as well as two iodothyronines (3,5-diiodothyronine (3,5-T2) and 3,3'-di-iodothyronine (3,3'-T2)) significantly influence rat liver mitochondrial activity.Liver oxidative capacity (measured as cytochrome oxidase activity/g wet tissue) in hypothyroid compared with normal rats was significantly reduced (21%, P>0.01) and the administration of T3 and both iodothyronines restored normal values. At the mitochondrial level, treatment with T3 stimulated respiratory activity (state 4 and state 3) and did not influence cytochrome oxidase activity. On the other hand, both the mitochondrial respiratory rate and specific cytochrome oxidase activity significantly increased in hypothyroid animals after treatment with 3,3'-T2 or 3,5-T2 (about 50 and 40% respectively). The actions of both iodothyronines were rapid and evident by 1 h after the injection. The hepatic mitochondrial protein content which decreased in hypothyroid rats (9.6 mg/g liver compared with 14.1 in normal controls, P