Toward Independence: Resubmission Rate of Unfunded National Heart, Lung, and Blood Institute R01 Research Grant Applications Among Early Stage Investigators.
Toward Independence: Resubmission Rate of Unfunded National Heart, Lung, and Blood Institute R01 Research Grant Applications Among Early Stage Investigators.
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DOI：
10.1097/acm.0000000000001025
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
Lauer MS
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文献类型：
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作者：
Boyington JE;Antman MD;Patel KC;Lauer MS
目前，美国国立卫生研究院（NIH）对生物医学研究的资助率较低，这引起了人们对新研究人员成为独立科学家的能力以及他们坚持努力获得资金的意愿的担忧。作者试图确定无资金支持的国家心肺血液研究所（NHLBI）早期研究者（ESI）独立研究资助（RO 1）申请的重新提交率，并确定重新提交的预测因素。作者采用回顾性队列研究设计，并从NIH电子研究管理来源检索了2010-2012财年提交的申请。他们将ESI申请人定义为那些之前没有获得R 01（或同等）资助，并且在完成最终研究学位或医学住院医师培训后10年内的人。ESI在NHLBI的申请有资格获得特殊的资金考虑，如果他们得分以上，但在10分之内，支付线。主要结果是在第一次R 01申请未能获得资金后重新提交申请。一半以上没有资金的申请是重新提交的。其中一些进行了讨论和“讨论”，在这些申请中，重新提交的唯一重要预测因素是百分位数。在2010-2012财年由NHLBI资助的ESI R 01赠款中，超过一半（59%）的百分比分数高于NHLBI支付线，但在10个百分点以内，并受益于特殊资助考虑。NHLBI ESI R 01补助金申请重新提交的唯一独立预测因子是百分位数评分;申请人人口统计学和机构因素不能预测重新提交。
The current, budget-driven low rate of the National Institutes of Health (NIH) funding for biomedical research has raised concerns about the ability of new investigators to become independent scientists and their willingness to persist in efforts to secure funding. The authors sought to determine resubmission rates for unfunded National Heart, Lung, and Blood Institute (NHLBI) early stage investigator (ESI) independent research grant (RO1) applications and to identify predictors of resubmission. The authors used a retrospective cohort study design and retrieved applications submitted in fiscal years 2010–2012 from NIH electronic research administrative sources. They defined ESI applicants as those who have received no prior R01 (or equivalent) funding and were within 10 years of completion of their terminal research degree or medical residency training. ESI applications at the NHLBI were eligible for special funding consideration if they scored above, but within ten points of, the payline. The primary outcome was application resubmission after failing to secure funding with the first R01 submission. Over half of the unfunded applications were resubmitted. Some of these were discussed and “percentiled,” and among these applications, the only significant predictor of resubmission was the percentile score. Over half (59%) of the ESI R01grants funded by NHLBI in FY-2010–2012 had percentile scores above, but within ten points of the NHLBI payline, and benefitted from the special funding considerations. The only independent predictor of resubmission of NHLBI ESI R01 grant applications was percentile score; applicant demographics and institutional factors were not predictive of resubmission.