Self-healing, stretchable and robust interpenetrating network hydrogels
Self-healing, stretchable and robust interpenetrating network hydrogels
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DOI：
10.1039/c8bm00872h
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发表时间：
2018-11-01
影响因子：
6.6
通讯作者：
Dove, Andrew P.
中科院分区：
文献类型：
--
作者：
Macdougall, Laura J.;Perez-Madrigal, Maria M.;Dove, Andrew P.
一种易于合成且具有抗压强度的可自我修复的可拉伸水凝胶系统在再生医学中具有巨大的潜力。在此，我们探索了添加市售的非功能化多糖作为合成自愈、可拉伸的聚乙二醇（PEG）互穿网络（ipn）作为细胞外基质（ECM）模拟物的途径。引入自愈和可拉伸特性，同时保持了原始的单网peg水凝胶的强大机械强度（最终压应力高达2.4 MPa）。这一过程无需对天然聚合物进行复杂和昂贵的功能化，从而增强了这些新型生物材料的转化适用性。
A self-healable stretchable hydrogel system that can be readily synthesized while also possessing robust compressive strength has immense potential for regenerative medicine. Herein, we have explored the addition of commercially available unfunctionalized polysaccharides as a route to synthesize self-healing, stretchable poly(ethylene glycol) (PEG) interpenetrating networks (IPNs) as extracellular matrix (ECM) mimics. The introduction of self-healing and stretchable properties has been achieved while maintaining the robust mechanical strength of the orginal, single network PEG-only hydrogels (ultimate compressive stress up to 2.4 MPa). This has been accomplished without the need for complicated and expensive functionalization of the natural polymers, enhancing the translational applicability of these new biomaterials.