Common and unique components of response inhibition revealed by fMRI
Common and unique components of response inhibition revealed by fMRI
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DOI：
10.1016/j.neuroimage.2005.01.054
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发表时间：
2005-08-15
期刊：
影响因子：
5.7
通讯作者：
Jonides, J
中科院分区：
文献类型：
--
作者：
Wager, TD;Sylvester, CYC;Jonides, J
抑制不适当反应的能力是认知控制的核心，但是否相同的大脑机制在不同的任务中介导抑制尚不清楚。我们提出的证据表明，一组共同的额叶和顶叶区域参与反应抑制在三个任务：去/不去的任务，侧翼任务，刺激-反应兼容性任务。区域包括双侧前额叶/额叶盖和前额叶，右背外侧和运动前区，以及顶叶皮质。在每个任务中，胰岛素活性与行为表现中的干扰成本呈正相关。主成分分析表明，在这些地区的个人差异，也与所有三个任务的表现呈正相关的连贯模式。然而，任务之间的相关性很低，无论是大脑活动还是表现。我们认为，共同的干扰检测和/或解决机制，从事跨任务，和任务间的相关性在行为表现是低的，因为他们混淆测量的共同机制与测量的个人偏见独特的每项任务。(c)2005年由Elsevier Inc.出版
The ability to inhibit inappropriate responses is central to cognitive control, but whether the same brain mechanisms mediate inhibition across different tasks is not known. We present evidence for a common set of frontal and parietal regions engaged in response inhibition across three tasks: a go/no-go task, a flanker task, and a stimulus -response compatibility task. Regions included bilateral anterior insula/frontal operculum and anterior prefrontal, right dorsolateral and premotor, and parietal cortices. Insula activity was positively correlated with interference costs in behavioral performance in each task. Principal components analysis showed a coherent pattern of individual differences in these regions that was also positively correlated with performance in all three tasks. However, correlations among tasks were low, for both brain activity and performance. We suggest that common interference detection and/or resolution mechanisms are engaged across tasks, and that inter-task correlations in behavioral performance are low because they conflate measurements of common mechanisms with measurements of individual biases unique to each task. (c) 2005 Published by Elsevier Inc.