Enzyme-Initiated Reversible Addition–Fragmentation Chain Transfer Polymerization
Enzyme-Initiated Reversible Addition–Fragmentation Chain Transfer Polymerization
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DOI：
10.1021/acs.macromol.5b01893
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发表时间：
2015-10
期刊：
影响因子：
5.5
通讯作者：
Baohua Zhang;Xinjun Wang;Anqi Zhu;K. Ma;Yuexian Lv;Xiao Wang;Zesheng An
中科院分区：
文献类型：
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作者：
Baohua Zhang;Xinjun Wang;Anqi Zhu;K. Ma;Yuexian Lv;Xiao Wang;Zesheng An
生物催化对于聚合物的可持续生产具有广阔的前景。据报道，酶引发的可逆加成-断裂链转移（RAFT）聚合。辣根过氧化物酶 (HRP) 通过过氧化氢催化乙酰丙酮 (ACAC) 的氧化，产生 ACAC 自由基，在合适的链转移剂存在下，在室温下在水性缓冲溶液中引发高效且良好控制的 RAFT 聚合。 HRP 引发的 RAFT 聚合的多功能性通过在各种条件下（包括均相溶液聚合和非均相分散聚合条件）对各种单体（包括活化程度较高和活化程度较低的单体）进行受控聚合来证明。在所有情况下，聚合都提供了优异的准一级动力学、可预测的分子量和窄的分子量分布。这种 HRP 引发的聚合通过 RAFT 机制进行的操作通过以下组合得到证实：
Biocatalysis is promising for sustainable production of polymers. Enzyme-initiated reversible addition–fragmentation chain transfer (RAFT) polymerization is reported. Horseradish peroxidase (HRP) catalyzes oxidation of acetylacetone (ACAC) by hydrogen peroxide to generate ACAC radicals, which in the presence of a suitable chain transfer agent initiate efficient and well-controlled RAFT polymerization in aqueous buffer solution at room temperature. The versatility of HRP-initiated RAFT polymerization was demonstrated by controlled polymerization of a wide range of monomers, including both more and less activated monomers, under a variety of conditions, including both homogeneous solution polymerization and heterogeneous dispersion polymerization conditions. In all cases, the polymerization afforded excellent pseudo-first-order kinetics, predictable molecular weights, and narrow molecular weight distributions. Operation via RAFT mechanism of this HRP-initiated polymerization was confirmed by a combination o...