M cell numbers increase after transfer of SPF mice to a normal animal house environment.
M cell numbers increase after transfer of SPF mice to a normal animal house environment.
复制标题
将 SPF 小鼠转移至正常动物房环境后，M 细胞数量增加。
作者：
M. Smith;P. James;D. Tivey
存在于小鼠Peyer氏斑的滤泡相关上皮(FAE)中的M细胞负责将肠道抗原运送到潜在的肠道相关淋巴组织(GALT)，以便随后由淋巴细胞和巨噬细胞进行处理。本实验使用一种新型的细胞标记技术，试图测量无特定病原体(SPF)和正常动物饲养(AH)的BALB/c小鼠FAE中M细胞的数量。结果显示，SPF小鼠转移到AH环境后7天，表观M细胞面积增加了3倍。这种变化不会显著影响杯状细胞所占的FAE面积。这些结果表明，在FAE中，通过外源抗原的存在可以选择性地增加M细胞的产生，这种作用在控制肠道感染的整体GALT反应中可能具有普遍的重要性。
M cells present in the follicle-associated epithelium (FAE) of mouse Peyer's patches take up and transport enteric antigens to the underlying gut-associated lymphoid tissue (GALT) for subsequent processing by lymphocytes and macrophages. Present experiments use a new type of cell-labeling technique in attempts to measure the number of M cells present in the FAE of specific pathogen-free (SPF) and normal animal house reared (AH) BALB/c mice. Results show the apparent M-cell area to increase threefold 7 days after transfer of SPF mice to an AH environment. This change takes place without significantly affecting the area of FAE occupied by goblet cells. It is suggested from these results that M-cell production can be selectively increased within the FAE through the presence of foreign antigens and that this effect could have general importance in controlling the overall GALT response to enteric infection.