Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience.
Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience.
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DOI：
10.2174/1567205012666150701102445
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发表时间：
2015
影响因子：
2.1
通讯作者：
Mosley TH
中科院分区：
文献类型：
--
作者：
Gottesman RF;Fornage M;Knopman DS;Mosley TH
报告的痴呆症发病率因种族而异，尽管大多数研究都没有关注仔细测量的结果，受到教育或其他人口统计学因素的干扰，也没有研究痴呆症的其他结果。在这篇综述中，我们将讨论社区动脉粥样硬化风险（ARIC）研究的经验，评估与中风，亚临床脑梗死，脑白质疏松症，以及认知变化和痴呆症有关的种族差异。ARIC是一个来自美国四个社区的15，792名参与者的双向队列，最初于1987-1989年招募，共进行了5次面对面访问（最近一次是在2011-2013年，每年进行电话随访）。我们将提供来自ARIC研究的证据，证明血管危险因素的不成比例的比率至少解释了这些观察到的种族差异中的一部分，但特定的危险因素，包括糖尿病，可能会对非洲裔美国人与白色参与者的大脑产生不同的影响。此外，我们将回顾一些种族差异的研究，重点是中风，小血管疾病和痴呆症的遗传学。
Reported rates of dementia differ by race, although most studies have not focused on carefully measured outcomes, confounding by education or other demographic factors, nor have they studied other outcomes to dementia. In this review we will discuss the experience in the Atherosclerosis Risk in Communities (ARIC) study evaluating racial disparities relating to stroke, subclinical brain infarction, leukoaraiosis, as well as cognitive change and dementia. ARIC is a biracial cohort of 15,792 participants from four U.S. communities, initially recruited in 1987–1989, and seen at a total of 5 in-person visits (most recently seen in 2011–2013 with annual follow-up phone calls. We will provide evidence from ARIC studies that disproportionate rates of vascular risk factors explain at least some of these observed disparities by race, but particular risk factors, including diabetes, may differentially affect the brain in African-American versus white participants. In addition, we will review some of the disparities by race in studies focusing on the genetics of stroke, small vessel disease, and dementia.