Insulin autoimmune syndrome after the third therapy with methimazole.
Insulin autoimmune syndrome after the third therapy with methimazole.
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第三次甲硫咪唑治疗后出现胰岛素自身免疫综合征。
DOI：
10.2169/internalmedicine.34.410
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发表时间：
1995
影响因子：
1.2
通讯作者：
N. Miyata
中科院分区：
文献类型：
--
作者：
M. Hakamata;M. Itoh;Y. Sudo;N. Miyata
1986年，一名26岁的女性被诊断患有格雷夫斯病，并接受了4个月的甲巯咪唑治疗。在丙硫脲嘧啶治疗4个月后，再次使用甲巯咪唑治疗。她的病情完全缓解了两年。她再次出现甲状腺功能亢进的症状，并再次开始使用甲巯咪唑治疗。治疗后第13天，患者出现低血糖发作并皮肤出疹。血浆葡萄糖57 mg/dl， 125i -胰岛素结合69%，游离IRI 196 microU/ml。患者有HLA-DRB1*0406。
In 1986, a 26-year-old female had been diagnosed as having Graves' disease and had been treated with methimazole for four months. After the treatment with propylthiouracil for another four months, she had been treated with methimazole once again. She was in complete remission for two years. She again experienced symptoms of hyperthyroidism, and treatment with methimazole was started again. On the thirteenth day after treatment, she experienced hypoglycemic attacks with skin eruption. The plasma glucose was 57 mg/dl, 125I-Insulin binding 69%, free IRI 196 microU/ml. The patient had the HLA-DRB1*0406.