STRESS-RELATED IMMUNE SUPPRESSION HEALTH IMPLICATIONS
STRESS-RELATED IMMUNE SUPPRESSION HEALTH IMPLICATIONS
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DOI：
10.1016/0889-1591(87)90002-x
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发表时间：
1987-01-01
影响因子：
15.1
通讯作者：
ET AL
中科院分区：
文献类型：
--
作者：
GLASER R;RICE J;ET AL
本研究采用为期一年的前瞻性设计来评估焦虑、免疫和疾病之间的联系。在第一次、第三次和第五次检查以及每次检查前1个月采集40名一年级医学生的连续血液样本。γ的产生有显著的减少。在检查时获得的豆豆蛋白a刺激淋巴细胞。eb病毒（EBV）抗体滴度在检查期间升高，提示潜伏性EBV的再激活，因此潜伏性病毒的细胞免疫控制较差。我们获得的数据表明，EBV转化的自体B淋巴细胞的记忆T淋巴细胞对T细胞的杀伤在检测期间也有所下降。一种淋巴因子，白细胞迁移抑制因子的活性，通常在2型单纯疱疹病毒感染的复发期间被抑制，在检查期间被改变，血浆和细胞内环AMP水平的增加与检查应激相关。自我报告的传染病症状发生率的增加也与检查时间有关。数据支持压力相关免疫抑制与健康之间的联系。
This study used a year-long prospective design to asses linkages among distress, immunity, and illness. Serial blood samples were collected from 40 first-year medical students at the first, third, and fifth examination periods, as well as 1 month before each. There were significant decrements in the production of .gamma.-interferon by concanavalin A-stimulated lymphocytes obtained at the time of examinations. Antibody titers to Epstein-Barr virus (EBV) increased during examination periods, suggesting reactivation of latent EBV and therefore poorer cellular immune control of latent virus. We obtained data that T-cell killing by memory T lymphocytes of EBV transformed autologous B lymphocytes also declined during examination periods. The activity of a lymphokine, leukocyte migration inhibition factors, normally suppressed during recrudescence of herpes simplex virus type 2 infections, was altered during examination periods and an increase in both plasma and intracellular levels of cyclic AMP associated with examination stress was observed. An increase in the incidence of self-reported symptoms of infectious illness was also associated with examination periods. The data support the linkages between stress-related immunosuppression and health.