Epigenetics of Aging and Aging-related Disease
Epigenetics of Aging and Aging-related Disease
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DOI：
10.1093/gerona/glu042
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发表时间：
2014-06-01
影响因子：
5.1
通讯作者：
Berger, Shelley L.
中科院分区：
文献类型：
--
作者：
Brunet, Anne;Berger, Shelley L.
衰老与多种人类疾病有关，包括癌症、糖尿病、心血管和神经退行性疾病。长期以来，衰老被认为是走向衰退和疾病的必经之路，但事实上，衰老具有惊人的可塑性。这种可塑性可以从一个新的角度来处理与年龄有关的疾病。虽然许多研究都集中在影响衰老的基因上，但衰老的非遗传调控越来越受到关注。具体而言，衰老与深刻的表观遗传变化有关，导致基因表达的改变和广泛基因组结构和表观基因组景观的干扰。这些表观遗传变化的潜在可逆性作为衰老的标志，为改变年龄相关疾病的轨迹提供了令人兴奋的机会。这篇简短的综述强调了衰老调控中的关键表观遗传参与者，以及利用表观遗传策略延迟和逆转主要衰老疾病的未来目标和挑战。
Aging is associated with a wide range of human disorders, including cancer, diabetes, cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road toward decline and diseases, aging is in fact remarkably plastic. Such plasticity could be harnessed to approach age-related diseases from a novel perspective. Although many studies have focused on the genes that impact aging, the nongenetic regulation of aging is gaining increasing attention. Specifically, aging is associated with profound epigenetic changes, resulting in alterations of gene expression and disturbances in broad genome architecture and the epigenomic landscape. The potential reversibility of these epigenetic changes that occur as a hallmark of aging offers exciting opportunities to alter the trajectory of age-related diseases. This short review highlights key epigenetic players in the regulation of aging, as well as both future goals and challenges to the utilization of epigenetic strategies to delay and reverse the main diseases of aging.