Comorbidity and clinical features in elderly patients with dementia: Differences according to dementia severity
Comorbidity and clinical features in elderly patients with dementia: Differences according to dementia severity
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DOI：
10.1007/s12603-009-0078-x
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发表时间：
2009-05-01
影响因子：
5.8
通讯作者：
Catena, J.
中科院分区：
文献类型：
--
作者：
Formiga, F.;Fort, I.;Catena, J.
评估老年痴呆症患者的共病和临床特征，以确定根据痴呆症严重程度的差异。通过病历审查进行观察性研究。巴塞罗那地区的八家医院。连续入院 515 名年龄 > 64 岁的痴呆症患者，其中 89.1% 居住在社区。我们收集了有关社会人口统计学变量、痴呆症类型、巴塞尔指数 (BI)、劳顿和布罗迪指数 (LI)、简易精神状态检查的数据(MMSE)、查尔森指数和长期处方药物总数。我们根据全球恶化量表 (GDS) 的疾病严重程度将人群分为两组：轻度至中度 (GDS 3-5) 和重度 (GDS 6-7)。共有 515 名参与者，其中 364 名女性 (70%) 和 151 名男性，平均年龄为 81 +/- 6 岁。慢性处方药总数为 5.6 +/- 2.4。平均查尔森指数得分为 2 +/- 1.2。将 270 名 (52.5%) GDS 评分为 3-5 分的患者与 245 名 GDS 评分为 6-7 分的患者进行比较。在多变量分析中，6-7 分的 GDS 评分与较差的 LI、BI 和 MMSE 评分以及较高的抗精神病药物治疗相关。重要的合并症在老年痴呆症患者中很常见。痴呆较严重的患者功能状态较差，精神安定药物使用频率较高。在痴呆患者的治疗中应考虑到医疗合并症。
To evaluate comorbidity and clinical features in elderly patients with dementia to determine differences according to dementia severity.Observational study with medical record review.Eight hospitals in the Barcelona area.515 consecutive admissions aged > 64 years with dementia, 89.1% of whom lived in the community.We collected data on sociodemographic variables, type of dementia, Barthel Index (BI), Lawton and Brody Index (LI), Mini-Mental State Examination (MMSE), Charlson Index and the total number of drugs chronically prescribed. We stratified the population into two groups according to disease severity with the Global Deterioration Scale (GDS): mild-moderate (GDS 3-5) and severe (GDS 6-7).There were a total of 515 participants of which 364 females (70%) and 151 males with a mean age of 81 +/- 6 years old. The total number of chronic prescription drugs was 5.6 +/- 2.4. The mean Charlson Index score was 2 +/- 1.2. The 270 (52.5%) patients with a GDS score of 3-5 were compared with the 245 patients with a GDS score of 6-7. In the multivariate analysis, a GDS score of 6-7 was associated with poorer LI, BI, and MMSE scores and greater neuroleptic therapy.Important comorbidity conditions are common in elderly individuals with dementia. The patients with more severe dementia had poor functional status and higher frequency of neuroleptic use. Medical comorbidities should be taken into account in the management of patients with dementia.