The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.
复制标题
使用连续流化学的合成活性药物成分（API）。
DOI：
10.3762/bjoc.11.134
复制
发表时间：
2015
影响因子：
2.7
通讯作者：
Baxendale IR
中科院分区：
文献类型：
--
作者：
Baumann M;Baxendale IR
连续流处理作为一项关键技术的实施改变了我们进行化学的方式，并扩大了我们的合成能力。因此，许多新的制备路线已经被设计成商业上相关的药物化合物，从而实现更有效和可再现的制造。这篇综述文章的目的是说明整体系统的方法和不同的应用程序的流动化学制备药物活性分子，展示了这种策略的价值，对每一个方面，从合成，在线分析和纯化，最终制定和压片。尽管本文将主要集中在大规模连续加工上，但将举例说明使用微型或中型流动反应器的其他选定合成方法，用于关键转化和过程控制。我们希望读者将获得一个赞赏的创新技术和转型性质，流动化学可以利用整个过程。
The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and reproducible manufacture. This review article aims to illustrate the holistic systems approach and diverse applications of flow chemistry to the preparation of pharmaceutically active molecules, demonstrating the value of this strategy towards every aspect ranging from synthesis, in-line analysis and purification to final formulation and tableting. Although this review will primarily concentrate on large scale continuous processing, additional selected syntheses using micro or meso-scaled flow reactors will be exemplified for key transformations and process control. It is hoped that the reader will gain an appreciation of the innovative technology and transformational nature that flow chemistry can leverage to an overall process.