Microbiologic characteristics of exfoliative toxin‐producing Staphylococcus aureus
Microbiologic characteristics of exfoliative toxin‐producing Staphylococcus aureus
复制标题
剥脱性产毒金黄色葡萄球菌的微生物学特征
DOI：
10.1097/00006454-198805000-00003
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
H. Yoshioka
中科院分区：
文献类型：
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作者：
K. Murono;K. Fujita;H. Yoshioka
研究了广泛性葡萄球菌性烫伤皮肤综合征和大疱性脓疱疮患者分离的74株金黄色葡萄球菌的剥脱毒素（ET）产生、噬菌体类型和抗生素敏感性。74株葡萄球菌分离株中，有61株通过新生小鼠试验和胶乳凝集法产生ET。ET-A阳性15株，ET-B阳性32株，ET-A和ET-B均阳性14株。61株产et菌株中，噬菌体ⅱ群27株（占44%），ⅲ群16株（占26%），ⅰ和ⅲ群14株（占23%）。在27株噬菌体II组菌株中，有14株产生ET-A， 13株同时产生ET-A和ET-B，但没有菌株单独产生ET-B。16株噬菌体III组中的15株和14株噬菌体I和III组均仅产生ET-B。结果表明，葡萄球菌的噬菌体类型与ET类型密切相关。典型的是，青霉素G对产et菌株的最低抑制浓度小于2罐/ml，而其他致病性葡萄球菌中有60 - 70%对青霉素G高度耐药。
Exfoliative toxin (ET) production, phage types and antibiotic susceptibilities of 74 strains of Staphylococcus aureus isolated from patients with generalized staphylococcal scalded skin syndrome or bullous impetigo were studied. Of 74 staphylococcal isolates, 61 strains were found to produce ET by the newborn mouse assay method and the latex agglutination method. Fifteen strains were positive for ET-A, 32 for ET-B and 14 for both ET-A and ET-B. Among 61 ET-producing strains 27 (44%) were classified as Phage Group II, 16 (26%) as Group III, and 14 (23%) as Groups I and III. Of 27 Phage Group II strains 14 produced ET-A and 13 produced both ET-A and ET-B, but no strain was positive solely for ET-B. On the other hand 15 of 16 Phage Group III strains and all 14 Phage Group I and III strains produced only ET-B. It was demonstrated that the phage types of staphylococci were closely related to ET types. Characteristically the minimal inhibitory concentrations of penicillin G against ET-producing strains were less than 2 jug/ml, in contrast to other pathogenic staphylococci, 60 to 70% of which are highly penicillin G-resistant.