A new simple method for assessing sudomotor function: Relevance in type 2 diabetes
A new simple method for assessing sudomotor function: Relevance in type 2 diabetes
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DOI：
10.1016/j.diabet.2010.05.004
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发表时间：
2010-12-01
影响因子：
7.2
通讯作者：
Bauduceau, B.
中科院分区：
文献类型：
--
作者：
Mayaudon, H.;Miloche, P-O;Bauduceau, B.
瞄准。-目前的运动功能测试太耗时，不能用于糖尿病患者的日常实践。EZSCAN是一项新的专利技术，通过反向离子导入和计时安培测量电化学皮肤电导(ESC)。本研究的目的是评估该方法在2型糖尿病患者中的敏感性、特异性和重复性，并与无糖尿病风险的对照组进行比较。-共有133名2型糖尿病患者和41名对照受试者接受了测试。参与者将手和脚放在镍电极上，然后在阳极上施加递增的低直流电2分钟。ESC是根据产生的电压和产生的电流计算出来的。用ROC曲线模型分析ESC诊断的准确性，用Bland-Altman分析评价ESC的重复性。-与对照组(68+/-16mSi和80+/-7mSi；P<；0.0001)相比，糖尿病患者手部和足部的ESC显著降低(分别为53+/-16mU Si和67+/-14mU Si)。ESC的灵敏度为75%，特异度为100%，在EZSCAN评分中，ROC曲线下面积为0.88，阈值为50%。手部和足部测量的变异系数分别为15%和7%。-EZSCAN良好的敏感性、特异性和重复性使其成为评估糖尿病患者自主神经病变的临床表现--运动功能障碍的一种可行的替代方法。这项测试需要
Aim. - The current sudomotor function tests are too time-consuming to be used for diabetic patients in daily practice. EZSCAN is a new, patented technology that measures electrochemical skin conductance (ESC) through reverse iontophoresis and chronoamperometry. The aim of the present study was to assess the sensitivity, specificity and reproducibility of the method in type 2 diabetic patients in comparison to control subjects with no risk of diabetes.Methods. - A total of 133 type 2 diabetic patients and 41 control subjects were tested. Participants placed their hands and feet on nickel electrodes; and an incremental low direct current was applied to the anode for 2 min. ESC was calculated from the resulting voltage and generated current. ESC diagnostic accuracy was analyzed by ROC curve modeling, and reproducibility was assessed using Bland-Altman analysis.Results. - The ESC of hands and feet was significantly reduced in diabetic patients (53 +/- 16 mu Si and 67 +/- 14 mu Si, respectively) compared with control subjects (68 +/- 16 mu Si and 80 +/- 7 mu Si, respectively; P < 0.0001). ESC values had a sensitivity of 75% and specificity of 100%, with an area under the ROC curve of 0.88 at a threshold of 50% on the EZSCAN scale. Coefficients of variation in hand and foot measurements were 15 and 7%, respectively.Conclusion. - The good sensitivity, specificity and reproducibility of EZSCAN make it a feasible alternative for assessing sudomotor dysfunction, a clinical manifestation of autonomic neuropathy in diabetic patients. The test takes