Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway
Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway
复制标题
DOI：
10.1111/j.1365-2249.2006.03257.x
复制
发表时间：
2007-01-01
影响因子：
4.6
通讯作者：
Agrewala, J. N.
中科院分区：
文献类型：
--
作者：
Sharma, S.;Chopra, K.;Agrewala, J. N.
白藜芦醇和姜黄素在癌症、炎症、糖尿病和各种其他疾病中的作用已得到充分证明。然而，它们对 T 细胞、B 细胞和巨噬细胞的免疫抑制作用尚未得到充分记录。在本研究中，我们确定了白藜芦醇和姜黄素对 T 细胞、B 细胞和巨噬细胞的影响。最引人注目的发现是白藜芦醇和姜黄素都能抑制 T 细胞、B 细胞和巨噬细胞的活性，增殖、抗体产生和淋巴因子分泌的显着抑制就证明了这一点。有趣的是，姜黄素主要通过下调CD28和CD80的表达以及上调CTLA-4来发挥免疫抑制作用。白藜芦醇还通过降低 CD28 和 CD80 的表达以及增加白细胞介素 (IL)-10 的产生来发挥作用。
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.