Thrombopoietin and the hematopoietic stem cell
Thrombopoietin and the hematopoietic stem cell
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DOI：
10.1196/annals.1349.018
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发表时间：
2005-01-01
期刊：
影响因子：
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通讯作者：
Kaushansky, K
中科院分区：
文献类型：
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作者：
Kaushansky, K
血小板生成素对干细胞存活、自我更新和扩增有利作用的分子机制尚不清楚。在已知HoxB4、HoxA9和血管内皮细胞生长因子对干细胞影响的基础上，我们探讨了TPO是否可能影响这些通路。我们发现TPO可增强HoxB4的转录，诱导HoxA9的核定位，并通过减少缺氧诱导因子的泛素化上调VEGF的表达。
The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, self-renewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways. We found that TPO enhances the transcription of HoxB4, induces the nuclear localization of HoxA9, and upregulates VEGF expression by reducing the ubiquination of hypoxia inducible factor.