NOVEL FINDINGS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH TUBERCULAR SERPIGINOUS-LIKE CHOROIDITIS
NOVEL FINDINGS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH TUBERCULAR SERPIGINOUS-LIKE CHOROIDITIS
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DOI：
10.1097/iae.0000000000001412
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发表时间：
2017-09-01
影响因子：
3.3
通讯作者：
Gupta, Vishali
中科院分区：
文献类型：
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作者：
Mandadi, Spoorti Krishna Reddy;Agarwal, Aniruddha;Gupta, Vishali
目的：分析和描述结核性脉络膜炎的光学相干断层扫描血管造影（OCTA）影像学特征，并与多模式成像进行比较。在这项前瞻性横断面研究中，使用OCTA对结核性脉络膜炎患者进行多模式成像（Optovue RTVue XR Avanti）、增强深度成像OCT（Heidelberg Spectralis）、眼底自发荧光、荧光素血管造影和吲哚菁绿色血管造影。在OCTA成像上分析脉络膜炎病变部位的视网膜脉络膜血管的独特形态学特征。结果：共18只眼（18例，男性16例）被纳入研究。正面OCTA图像显示视网膜色素上皮-Bruch膜层下的离散流空区域，提示脉络膜毛细血管灌注不足，与吲哚菁绿色血管造影吻合良好，尤其是在慢性期。使用OCTA在愈合晚期的病变中观察到其他信息，如保留的脉络膜毛细血管、血管簇和缠结的血管。与吲哚菁绿色血管造影相比，OCTA对脉络膜毛细血管萎缩区域的显示更清晰，并与增强深度成像OCT相关性良好。结论：OCTA图像可提供结节性脉络膜炎视网膜脉络膜血管的高分辨率结构信息。从OCTA图像获得的形态信息与其他成像技术（如吲哚菁绿色血管造影和增强深度成像OCT）相关性良好，并可作为其补充。
Purpose: To analyze and describe the imaging characteristics of tubercular serpiginous-like choroiditis using optical coherence tomography angiography (OCTA) and to compare these findings with multimodal imaging.Methods: In this prospective cross-sectional study, multimodal imaging was performed in subjects with tubercular serpiginous-like choroiditis using OCTA (Optovue RTVue XR Avanti), enhanced-depth imaging OCT (Heidelberg Spectralis), fundus autofluorescence, fluorescein angiography, and indocyanine green angiography. Distinct morphologic features of the retinochoroidal vasculature at the sites of choroiditis lesions were analyzed on OCTA imaging. Multimodal imaging analysis was performed to study the changes observed on OCTA.Results: Eighteen eyes (18 subjects, 16 males) were included in the study. The en face OCTA images demonstrated discrete areas of flow void beneath the retinal pigment epithelium-Bruch membrane layer suggestive of choriocapillaris hypoperfusion that corresponded well with indocyanine green angiography, especially in the chronic phase. Additional information such as areas of preserved choriocapillaris, vascular tufts, and tangled vessels were observed using OCTA among lesions in advanced stages of healing. Compared with indocyanine green angiography, the areas of choriocapillaris atrophy appeared better defined on OCTA and correlated well with enhanced-depth imaging OCT.Conclusion: The OCTA images provide high-resolution structural information of the retinochoroidal vasculature in tubercular serpiginous-like choroiditis. Morphologic information obtained from OCTA images correlates well with and supplements other imaging techniques such as indocyanine green angiography and enhanced-depth imaging OCT.