Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability
Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability
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DOI：
10.1038/3260
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发表时间：
1998-11-01
期刊：
影响因子：
82.9
通讯作者：
Feinberg, AP
中科院分区：
文献类型：
--
作者：
Cui, HM;Horon, IL;Feinberg, AP
印迹缺失（LOI）是某些癌症的表观遗传学改变，涉及印迹基因的亲本来源特异性表达的缺失。我们观察到胰岛素样生长因子-II基因的LOI在12个27信息结直肠癌患者（44%），以及在匹配的正常结肠粘膜的LOI患者在他们的癌症，并在外周血样本的4名患者。11例微卫星不稳定性肿瘤中有10例（91%）出现LOI，而16例无微卫星不稳定性肿瘤中只有2例（12%）出现LOI（P< 0.001）。对照组中16例结肠粘膜和15例血液标本中分别只有2例和2例检出LOI（12%，P <0.001）。这些数据表明，在肿瘤和正常组织中的LOI确定大多数结直肠癌患者的肿瘤中的微卫星不稳定性，LOI可以确定一个重要的子集的人口与癌症或发展癌症的风险。
Loss of imprinting (LOI) is an epigenetic alteration of some cancers involving loss of parental origin-specific expression of imprinted genes. We observed LOI of the insulin-like growth factor-ii gene in twelve of twenty-seven informative colorectal cancer patients (44%), as well as in the matched normal colonic mucosa of the patients with LOI in their cancers, and in peripheral blood samples of four patients. Ten of eleven cancers (91%) with microsatellite instability showed LOI, compared with only two of sixteen tumors (12%) without microsatellite instability (P< 0.001). Control patients without cancer showed LOI in colonic mucosa of only two of sixteen cases (12%, P < 0.001) and two of fifteen blood samples (13%, P < 0.001). These data suggest that LOI in tumor and normal tissue identifies most colorectal cancer patients with microsatellite instability in their tumors, and that LOI may identify an important subset of the population with cancer or at risk of developing cancer.