A PHARMACOLOGICAL DOSE OF MELATONIN INCREASES PRL LEVELS IN MALES WITHOUT ALTERING THOSE OF GH, LH, FSH, TSH, TESTOSTERONE OR CORTISOL
A PHARMACOLOGICAL DOSE OF MELATONIN INCREASES PRL LEVELS IN MALES WITHOUT ALTERING THOSE OF GH, LH, FSH, TSH, TESTOSTERONE OR CORTISOL
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DOI：
10.1159/000124808
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发表时间：
1987-08-01
影响因子：
4.1
通讯作者：
CROWLEY, WF
中科院分区：
文献类型：
--
作者：
WALDHAUSER, F;LIEBERMAN, HR;CROWLEY, WF
由于褪黑激素（aMT）对人体内分泌系统的影响的报告很少和不一致，急性，药理剂量的aMT对健康男性的各种激素水平的影响进行了检查，在3个不同的实验。实验1：8名志愿者口服80或240 mg结晶aMT。分别于治疗前、治疗中、治疗后检测血清aMT、PRL、LH、FSH和睾酮水平。虽然aMT增加了至少1,500倍以上的基础水平，只有PRL显着和持续升高后，aMT治疗，而血清中的其他激素水平没有改变。实验II：在2名受试者中，在aMT给药（240 mg p.o.）前6 h和给药后6 h监测LH的脉冲式分泌模式。LH脉冲的幅度和频率均不受松果体激素的影响。实验三：在14名志愿者中，在口服240 mg aMT后一次和安慰剂后一次检测血清PRL、GH、TSH和皮质醇浓度。血清PRL水平显着高于aMT后比安慰剂; GH显示轻微的，但不显着的趋势后MT升高，而其他激素没有改变。急性药理剂量的aMT引起血清PRL水平的孤立升高，并可能轻微增加GH。垂体性腺轴的激素以及TSH和皮质醇不被aMT改变。
Since reports on the influence of melatonin (aMT) on the human endocrine system are scant and inconsistent, the effect of an acute, pharmacological dose of aMT on various hormone levels in healthy males was examined in 3 different experiments. Experiment 1: 80 or 240 mg of crystalline aMT were administered per os to 8 volunteers. Before, during and after this treatment, serum levels of aMT, PRL, LH, FSH and testosterone were examined. Although aMT increased at least 1,500-fold over basal levels, only PRL was significantly and consistently elevated after aMT treatment, whereas serum levels of the other hormones were not altered. Experiment II: in 2 subjects, the pulsatile secretion pattern of LH was monitored for 6 h before and 6 h after aMT administration (240 mg p.o.). Neither the amplitude nor the frequency of LH pulses was influenced by the pineal hormone. Experiment III: in 14 volunteers, serum PRL, GH, TSH and cortisol concentrations were examined, once after oral administration of 240 mg aMT and once after placebo. Serum PRL levels were significantly higher after aMT than after placebo; GH showed a slight but not significant trend towards elevation after a MT, whereas other hormones were not altered. An acute pharmacological dose of aMT causes isolated elevation of serum PRL levels and may slightly increase GH. Hormones of the pituitary gonadal axis as well as TSH and cortisol are not altered by aMT.