GALANIN - NEUROMODULATORY AND DIRECT CONTRACTILE EFFECTS ON SMOOTH-MUSCLE PREPARATIONS
GALANIN - NEUROMODULATORY AND DIRECT CONTRACTILE EFFECTS ON SMOOTH-MUSCLE PREPARATIONS
复制标题
DOI：
10.1111/j.1476-5381.1985.tb09455.x
复制
发表时间：
1985-01-01
影响因子：
7.3
通讯作者：
WAHLESTEDT, C
中科院分区：
文献类型：
--
作者：
EKBLAD, E;HAKANSON, R;WAHLESTEDT, C
1研究了甘丙肽（一种新分离的神经肽）及其片段（甘丙肽1-10）对各种离体平滑肌的作用。观察到直接运动效应以及对电诱导（神经元介导）反应（神经调节效应）的影响。2 gatanin和galanin 1-10均能引起大鼠空肠纵肌的强烈收缩反应。这种作用是直接作用于平滑肌的。3甘丙肽可抑制内源性P物质和乙酰胆碱介导的豚鼠结肠带对电刺激的收缩反应。在兔虹膜括约肌，甘丙肽减少乙酰胆碱介导的，但不是P物质介导的电刺激引起的收缩。神经调节作用似乎是突触前的，并且需要甘丙肽分子的整个或可能仅C-末端部分，因为甘丙肽1-10是无效的。4家兔股动、静脉、胃网膜动脉、基底动脉、豚鼠气管和主支气管对甘丙肽或甘丙肽1-10均无反应。
1 The effects of galanin, a newly isolated neuropeptide, and of a galanin fragment (galanin 1-10) were studied on various smooth muscle preparations in vitro. Direct motor effects as well as effects on electrically induced (neuronally mediated) responses (neuromodulatory effects) were observed. 2 Both gatanin and galanin 1-10 evoked a strong contractile response in rat jejunal longitudinal muscle. This effect was a direct one on the smooth muscle. 3 Addition of galanin to guine-pig taenia coli inhibited the contractile responses to electrical stimulation, mediated by endogenous substance P and acetylcholine. In the rabbit iris sphincter, galanin reduced the acetylcholine-mediated but not the substance P-mediated contraction evoked by electrical stimulation. The neuromodulatory effects seem to be presynaptic and require the whole or possibly only the C-terminal part of the galanin molecule, since galanin 1-10 was ineffective. 4 Rabbit femoral artery and vein, gastroepiploic and basilar arteries and guinea-pig trachea and main bronchi did not respond to either galanin or galanin 1-10.