The inhibition of streptococcal desoxyribonuclease by rabbit and human antisera.
The inhibition of streptococcal desoxyribonuclease by rabbit and human antisera.
复制标题
兔子和人类抗血清对链球菌去氧核糖核酸酶的抑制作用。
DOI：
10.1084/jem.90.6.543
复制
发表时间：
1949-12
影响因子：
15.3
通讯作者：
McCARTY, M
中科院分区：
文献类型：
--
作者：
McCARTY, M
兔抗血清对部分纯化的链球菌脱氧核糖核酸酶抑制其底物的酶的作用。胰腺脱氧核糖核酸酶的活性不受这些抗血清的影响。类似地，抗胰腺核酸酶的抗体不抑制链球菌酶。某些患者在链球菌感染后产生链球菌脱氧核糖核酸酶抑制性抗体，偶尔滴度很高，尽管显示抗体应答的患者比例似乎低于链激酶和链球菌溶血素O的情况。在一组90名猩红热流行病患者中，对脱氧核糖核酸酶的抗体反应模式与链激酶和链球菌溶血素O的抗体反应模式进行了比较。
Rabbit antisera against partially purified streptococcal desoxyribonuclease inhibit the action of the enzyme on its substrate. The activity of pancreatic desoxyribonuclease is not affected by these antisera. Similarly antibody against pancreatic nuclease does not inhibit the streptococcal enzyme. Certain patients develop inhibitory antibody to streptococcal desoxyribonuclease following streptococcal infections, occasionally in very high titer, although the proportion of patients showing an antibody response appears to be lower than in the case of streptokinase and streptolysin O. The pattern of antibody response to desoxyribonuclease has been compared to that of streptokinase and streptolysin O in a group of ninety patients from an epidemic of scarlet fever.