Periodic microstimulation of single mechanoreceptive afferents produces frequency-following responses in human EEG
Periodic microstimulation of single mechanoreceptive afferents produces frequency-following responses in human EEG
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DOI：
10.1152/jn.1997.77.1.137
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发表时间：
1997-01-01
影响因子：
2.5
通讯作者：
Folger, SE
中科院分区：
文献类型：
--
作者：
Kelly, EF;Trulsson, M;Folger, SE
在初级体感皮层附近获得了头皮脑电图的密集多通道记录，对单个人类受试者的正中神经中的单个、生理特征的皮肤机械感受传入进行时间锁定的重复训练微刺激。对快速适应一型和慢速适应一型传入神经的跨试验平均值的频域分析显示，在刺激频率下，脑电图中存在显着的、按拓扑结构组织的“驱动”反应，而这种反应在各种统计和实验控制条件下消失。这些反应还表现出试验间和试验内振幅的系统性下降，以及头皮地形的有序变化，作为手上传入感受野位置的函数。观察到的反应特性可以根据微刺激施加在皮层上的传入驱动模式的特征进行初步解释。
Dense multichannel recordings of scalp electroencephalogram were obtained in the vicinity of primary somatosensory cortex, time-locked to repetitive train microstimulation of single, physiologically characterized skin mechanoreceptive afferents in the median nerve of a single human subject. Frequency-domain analysis of cross-trial averages for fast-adapting type one and slowly adapting type one afferents revealed prominent, topographically organized ''driving'' responses in the electroencephalogram at the frequency of stimulation, which vanished under various statistical and experimental control conditions. The responses also exhibited systematic declines in amplitude both across and within trials, and orderly changes in scalp topography as a function of the location of afferents' receptive fields on the hand. The observed response properties are tentatively explained in terms of characteristics of the pattern of afferent drive impressed on the cortex by microstimulation.