Profilin: many facets of a small protein.
Profilin: many facets of a small protein.
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DOI：
10.1007/s12551-020-00723-3
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发表时间：
2020-08-01
影响因子：
--
通讯作者：
Moens, Pierre Dj
中科院分区：
文献类型：
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作者：
Davey, Rhonda J;Moens, Pierre Dj
Profilin是一种普遍表达的蛋白，被认为是肌动蛋白聚合的关键调节因子。肌动蛋白细胞骨架参与几乎所有的细胞过程，包括运动、内吞、代谢、信号转导和基因转录。因此，profilin在细胞中的作用超越了其调节肌动蛋白动力学的直接和基本功能。本文将重点介绍Profilin 1及其配体在细胞质膜、细胞质和细胞核中的相互作用，以及Profilin在这些细胞区室中的活性调控。我们将讨论profilin在细胞信号通路中的相互作用，并强调这种小的必需蛋白与其在细胞骨架组织和动力学中的作用相结合的多种功能中细胞环境的重要性。我们将回顾一些控制profilin表达的机制以及profilin表达改变在癌症生物学和其他病理学方面的意义。
Profilin is a ubiquitously expressed protein well known as a key regulator of actin polymerisation. The actin cytoskeleton is involved in almost all cellular processes including motility, endocytosis, metabolism, signal transduction and gene transcription. Hence, profilin's role in the cell goes beyond its direct and essential function in regulating actin dynamics. This review will focus on the interactions of Profilin 1 and its ligands at the plasma membrane, in the cytoplasm and the nucleus of the cells and the regulation of profilin activity within those cell compartments. We will discuss the interactions of profilin in cell signalling pathways and highlight the importance of the cell context in the multiple functions that this small essential protein has in conjunction with its role in cytoskeletal organisation and dynamics. We will review some of the mechanisms that control profilin expression and the implications of changed expression of profilin in the light of cancer biology and other pathologies.