The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila
The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila
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DOI：
10.1038/ni1237
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发表时间：
2005-09-01
影响因子：
30.5
通讯作者：
Imler, JL
中科院分区：
文献类型：
--
作者：
Dostert, C;Jouanguy, E;Imler, JL
果蝇对细菌和真菌感染的反应涉及两种信号通路Toll和Imd，它们都激活转录因子NF-κ B家族的成员。在这里，我们研究了果蝇感染果蝇C病毒的整体转录反应。病毒感染诱导了一组与Toll或Imd途径调节的基因不同的基因，并触发了信号转导子和转录激活子（STAT）DNA结合活性。遗传实验表明，Jak激酶Hopscotch参与控制感染果蝇中的病毒载量，并且是诱导某些病毒调节基因所必需的，但不是充分的。我们的研究结果表明，除了Toll和Imd，第三，进化保守的先天免疫途径在果蝇和计数器病毒感染的功能。
The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate members of the transcription factor NF- kappa B family. Here we have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct from those regulated by the Toll or Imd pathways and triggered a signal transducer and activator of transcription ( STAT) DNA- binding activity. Genetic experiments showed that the Jak kinase Hopscotch was involved in the control of the viral load in infected flies and was required but not sufficient for the induction of some virus- regulated genes. Our results indicate that in addition to Toll and Imd, a third, evolutionary conserved innate immunity pathway functions in drosophila and counters viral infection.