Mechanism of zirconia microgroove surface structure for osseointegration
Mechanism of zirconia microgroove surface structure for osseointegration
复制标题
氧化锆微槽表面结构的骨整合机制
DOI：
10.1016/j.mtadv.2021.100159
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发表时间：
2021-08-25
影响因子：
10
通讯作者：
Yu，Youcheng
中科院分区：
文献类型：
--
作者：
Sun，Yang;Sun，Jian;Yu，Youcheng
氧化锆种植体具有抗菌、耐腐蚀、耐磨损、美观等优点，具有广阔的应用前景。改善材料表面形态以促进骨整合一直是种植体研究与开发的重点。本文采用飞秒激光刻蚀技术在氧化锆材料表面制备了微槽（MG）图案。镁合金的表面结构减少了金属杂质，增加了材料的粗糙度和亲水性。氧化锆表面的mg能促进MC3T3-E1细胞的粘附、增殖和成骨分化。在模拟临床应用中，氧化锆表面的微沟槽结构可以减少周围骨组织的应力，导致良好的骨整合。差异基因表达分析为研究成骨细胞分化调控机制提供了分子基础。总之，这种氧化锆表面的MG结构在种植牙领域具有很大的临床转化潜力。
Zirconia implants have a promising perspective because of their antibacterial, corrosion resistance, wear resistance, and excellent esthetic effects. Improving the surface morphology of materials to promote osseointegration has always been the focus of implant research and development. Here, we fabricated microgroove (MG) patterns on the surface of zirconia materials using femtosecond laser etching technology. The surface structure of the MGs reduces metal impurities and increases the roughness and hydrophilicity of the material. The MGs on the surface of zirconia can promote the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells. In simulated clinical applications, the micro-groove structure on the surface of zirconia can reduce the stress of the surrounding bone tissue and lead to good osseointegration. Differential gene expression analysis provides a molecular basis for the mechanism research that regulates osteoblast differentiation. In short, this MG structure on the surface of zirconia has great potential for clinical transformation in the field of dental implants.