Delta/notch-like epidermal growth factor-related receptor promotes sternness to facilitate breast cancer progression
Delta/notch-like epidermal growth factor-related receptor promotes sternness to facilitate breast cancer progression
复制标题
Delta/Notch样表皮生长因子相关受体促进干性促进乳腺癌进展
DOI：
10.1016/j.cellsig.2019.109389
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发表时间：
2019
影响因子：
4.8
通讯作者：
Shengrong Sun
中科院分区：
文献类型：
--
作者：
Lijun Wang;Qi Wu;Zhiyu Li;Si Sun;Jingping Yuan;Juanjuan Li;Yimin Zhang;Dehua Yu;Changhua Wang;Shengrong Sun
DNER（Delta/Notch-like epidermal growth factor，EGF）-related receptor，是一种神经元特异性跨膜蛋白，携带细胞外EGF样重复序列。DNER在乳腺癌中的作用尚未得到评价。目前的研究表明，乳腺癌组织中DNER的表达显着高于其在乳腺良性疾病的表达，并与乳腺癌患者的无复发生存率（RFS）差。结果表明，DNER在体外可促进乳腺癌细胞的增殖和转移，在体内可显著促进肿瘤的生长。我们的研究发现DNER可以通过激活Girdin/PI 3 K/AKT信号通路，进而调控几个涉及肿瘤干细胞特性的关键基因，促进乳腺癌细胞的增殖和转移。DNER促进乳腺癌的生长和转移，为DNER抑制剂在乳腺癌治疗中的应用提供了理论依据。
DNER, Delta/Notch-like epidermal growth factor (EGF)-related receptor, is a neuron-specific transmembrane protein carrying extracellular EGF-like repeats. The function of DNER in breast cancer has not been evaluated. The present study demonstrates that the expression of DNER in breast cancer tissue is significantly higher than its expression in breast benign disease and is associated with poor recurrence-free survival (RFS) of breast cancer patients. It demonstrated that DNER could enhance the proliferation and metastasis of breast cancer cells in vitro and significantly increases tumor growth in vivo. Our study uncovered that DNER can promote breast cancer cells proliferation and metastasis by activating Girdin/PI3K/AKT signaling and subsequently regulating several key genes involving the characters of cancer stem cells. Taken together, DNER promotes breast cancer growth and metastasis, which provided a theoretical basis for future applications of DNER inhibitors in the treatment of breast cancer.