Oral fluid-based biomarkers of alveolar bone loss in periodontitis
Oral fluid-based biomarkers of alveolar bone loss in periodontitis
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DOI：
10.1196/annals.1384.028
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Giannobile, William V.
中科院分区：
文献类型：
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作者：
Kinney, Janet S.;Ramseier, Christoph A.;Giannobile, William V.
牙周病是一种细菌引起的慢性炎症性疾病，影响牙齿周围的软硬支撑结构。如果不治疗，最终的结果是牙槽骨丢失和脱落的涉及牙齿。传统的牙周诊断方法包括临床参数和X线片的评估。尽管有效，但这些常规技术固有地受限于仅可确定疾病状态的历史观点而非当前评估。在使用口腔液作为可能的生物样品用于客观测量当前疾病状态、治疗监测和预后指标方面的进展已经将唾液和其他基于口腔的液体推到了技术的最前沿。口腔液含有牙周病的局部和全身来源的介质，包括微生物、宿主反应和骨特异性再吸收标记物。虽然口腔液中的大多数生物标志物代表炎症介质，但几种特定的胶原降解和骨转换相关分子已成为牙周病活动的可能措施。例如，吡啶啉交联羧基末端肽（ICTP）与疾病的临床特征高度相关，并且响应于干预治疗而降低，并且已显示具有对未来可能的疾病活动的预测特性。一个可预见的好处，口腔液为基础的牙周诊断将是识别高度敏感的个人之前，明显的疾病。及时发现和诊断疾病可能会显著影响牙周病患者的临床管理，提供更早，侵入性更小，更具成本效益的治疗方法。
Periodontal disease is a bacteria-induced chronic inflammatory disease affecting the soft and hard supporting structures encompassing the teeth. When left untreated, the ultimate outcome is alveolar bone loss and exfoliation of the involved teeth. Traditional periodontal diagnostic methods include assessment of clinical parameters and radiographs. Though efficient, these conventional techniques are inherently limited in that only a historical perspective, not current appraisal, of disease status can be determined. Advances in the use of oral fluids as possible biological samples for objective measures of current disease state, treatment monitoring, and prognostic indicators have boosted saliva and other oral-based fluids to the forefront of technology. Oral fluids contain locally and systemically derived mediators of periodontal disease, including microbial, host-response, and bone-specific resorptive markers. Although most biomarkers in oral fluids represent inflammatory mediators, several specific collagen degradation and bone turnover-related molecules have emerged as possible measures of periodontal disease activity. Pyridinoline cross-linked carboxyterminal telopeptide (ICTP), for example, has been highly correlated with clinical features of the disease and decreases in response to intervention therapies, and has been shown to possess predictive properties for possible future disease activity. One foreseeable benefit of an oral fluid-based periodontal diagnostic would be identification of highly susceptible individuals prior to overt disease. Timely detection and diagnosis of disease may significantly affect the clinical management of periodontal patients by offering earlier, less invasive, and more cost-effective treatment therapies.