Die Diagnose der Frontotemporalen Demenz
Die Diagnose der Frontotemporalen Demenz
复制标题
额颞叶疾病诊断
DOI：
10.1055/s-2002-28432
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发表时间：
2002
影响因子：
0.6
通讯作者：
E. Donnemiller
中科院分区：
文献类型：
--
作者：
T. Benke;E. Donnemiller
额颞叶变性(FTDL)是一种以行为改变和认知能力丧失为主要特征的神经退行性疾病。三种主要的临床症状已被确定，额颞性痴呆(FTD)，其中社会行为的变化占主导地位，语义性痴呆(SD)，其特征是丧失语义知识，以及原发性进行性失语症(PPA)，语言的语音和句法方面的障碍。FTLD各亚型均具有潜伏性发病和渐进性。本文列举了三种FTLD亚型的临床症状和主要表现，并讨论了其诊断和鉴别诊断的困难。FTLD的诊断是基于隆德和曼彻斯特组的临床共识标准[1，2]，神经放射学和神经心理学检查。
Frontotemporal Lobar Degeneration (FTDL) is a neurodegenerative disorder which is predominantly characterized by changes in behaviour and loss of cognitive abilities. Three major clinical syndromes have been identified, Frontotemporal dementia (FTD), in which changes in social behaviour predominate, Semantic Dementia (SD) which is characterized by a loss of semantic knowledge, and Primary Progressive Aphasia (PPA), a disorder of phonological and syntactic aspects of language. All subtypes of FTLD have insiduous onset and stepwise progression. The present review lists the clinical symptoms and main findings of the three FTLD-subtypes, and discusses the difficulties of their diagnosis and differential diagnosis. The diagnosis of FTLD is based on the clinical consensus criteria of the Lund and Manchester groups [1,2], neuroradiological and neuropsychological investigations.