BAG3 is upregulated by c-Jun and stabilizes JunD
BAG3 is upregulated by c-Jun and stabilizes JunD
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BAG3 被 c-Jun 上调并稳定 JunD
DOI：
10.1016/j.bbamcr.2013.10.007
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发表时间：
2013-12-01
影响因子：
5.1
通讯作者：
Wang, Hua-Qin
中科院分区：
文献类型：
--
作者：
Li, Chao;Li, Si;Wang, Hua-Qin
BAG 3在许多细胞过程中起调节作用，包括细胞增殖、凋亡、粘附和迁移、上皮-间质转化（EMT）、自噬激活和病毒感染。AP-1转录因子参与多种重要的生物学过程，包括细胞分化、增殖、凋亡和肿瘤发生。最近，有报道AP-1蛋白c-Jun抑制自噬并增强饥饿介导的凋亡性细胞死亡。然而，其分子机制仍不清楚。本研究首次证实血清饥饿通过c-Jun在转录水平下调BAG 3的表达，并发现BAG 3稳定了JunD的mRNA，这是BAG 3促进血清饥饿介导的生长抑制的部分原因。(C)2013爱思唯尔有限公司版权所有。
BAG3 plays a regulatory role in a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, epithelial-mesenchymal transition (EMT), autophagy activation, and virus infection. The AP-1 transcription factors are implicated in a variety of important biological processes including cell differentiation, proliferation, apoptosis and oncogenesis. Recently, it has been reported that AP-1 protein c-Jun inhibits autophagy and enhances apoptotic cell death mediated by starvation. However, the molecular mechanisms remain unclear. For the first time, the current study demonstrated that serum starvation downregulated BAG3 at the transcriptional level via c-Jun. In addition, the current study reported that BAG3 stabilized JunD mRNA, which was, at least in part, responsible for the promotion of serum starvation mediated-growth inhibition by BAG3. (C) 2013 Elsevier B.V. All rights reserved.