Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection.
Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection.
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记忆 CD8 T 细胞是病毒感染部位淋巴结引流的看门人。
DOI：
10.1073/pnas.0701822104
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发表时间：
2007
影响因子：
11.1
通讯作者：
Sigal,LuisJ
中科院分区：
文献类型：
--
作者：
Xu,Ren-Huan;Fang,Min;Klein-Szanto,Andres;Sigal,LuisJ
目前还不确定免疫力如何保护免受系统性病毒性疾病。在这里，我们证明，在没有持续性病毒的情况下，不仅抗体，而且还通过长寿命的记忆CD8+T细胞的回忆反应，防止鼠痘，一种由鼠痘病毒引起的疾病，一种人类天花病毒的近亲。此外，我们表明，为了保护，召回CD8+T细胞直接杀死淋巴结引流的主要感染部位，从而遏制系统性病毒传播的目标。因此，我们的工作为一个模型提供了基础，在这个模型中，淋巴结不仅是淋巴细胞被激活和增殖的器官，而且也是对抗病毒传播的主要斗争发生的场所。
It is uncertain how immunity protects against systemic viral diseases. Here, we demonstrate that in the absence of persistent virus, not only antibodies but also recall responses by long-lived memory CD8+T cells prevent mousepox, a disease caused by ectromelia virus, a close relative of the virus of human smallpox. Moreover, we show that to protect, recall CD8+T cells directly kill targets in the lymph node draining the primary site of infection thus curbing systemic viral spread. Therefore, our work provides the basis for a model where lymph nodes are not just organs where lymphocytes become activated and proliferate but also the sites where a major fight against virus spread takes place.