Biocompatible silk fibroin scaffold prepared by reactive inkjet printing
Biocompatible silk fibroin scaffold prepared by reactive inkjet printing
复制标题
DOI：
10.1007/s10853-016-0121-3
复制
发表时间：
2016-06
影响因子：
4.5
通讯作者：
Patrick M Rider;Yu Zhang;C. Tse;Yi Zhang;D. Jayawardane;J. Stringer;J. Callaghan;I. Brook;Cheryl A Miller;Xiubo Zhao;Patrick J. Smith
中科院分区：
文献类型：
--
作者：
Patrick M Rider;Yu Zhang;C. Tse;Yi Zhang;D. Jayawardane;J. Stringer;J. Callaghan;I. Brook;Cheryl A Miller;Xiubo Zhao;Patrick J. Smith
最近有研究表明，再生丝素（RSF）水溶液可以用喷墨打印机打印。在本文中，我们展示了一种可替代的反应性喷墨打印方法，该方法通过β片浓度控制RSF结晶度。通过反应性喷墨打印RSF水溶液和甲醇的交替打印，成功地生产了一种生物相容性薄膜。通过打印不同比例的RSF与甲醇实现了对β-薄片结构形成的控制，并通过傅里叶变换红外光谱进行了证实。通过成纤维细胞在其表面的生长，证明了打印丝支架的生物相容性。
It has recently been shown that regenerated silk fibroin (RSF) aqueous solution can be printed using an inkjet printer. In this communication, we demonstrate an alternative reactive inkjet printing method that provides control over RSF crystallinity through β-sheet concentration. A biocompatible film has successfully been produced through the alternate printing of RSF aqueous solution and methanol using reactive inkjet printing. Control over the formation of the β-sheet structure was achieved by printing different ratios of RSF to methanol and was confirmed using Fourier Transform Infra Red spectroscopy. The biocompatibility of the printed silk scaffold was demonstrated by the growth of fibroblast cells upon its surface.