Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: The OAB-q
Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: The OAB-q
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DOI：
10.1023/a:1016370925601
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发表时间：
2002-09-01
影响因子：
3.5
通讯作者：
Abrams, P
中科院分区：
文献类型：
--
作者：
Coyne, K;Revicki, D;Abrams, P
目的：膀胱过度活动症(OAB)以尿频和尿急为特征，有无尿失禁，已被证明对健康相关生活质量(HRQL)有显著影响。目前，还没有专门针对OAB的问卷来评估OAB的所有症状；因此，我们试图评估新开发的OAB HRQL问卷的心理测量学特性。方法：自编的OAB-Q由33个条目组成，包含症状困扰和HRQL量表。OAB-Q和SF-36都是由参与者从两个来源完成的：(1)在随机数字拨号电话调查中筛选出OAB阳性的社区样本，并参与了临床验证研究(n=254)；(2)关于患者寻求治疗OAB症状的临床研究(基线评估)(n=736)。采用项目分析和探索性因素分析评价问卷的子量表结构。采用心理测量学评价其信度和效度。结果：74%的样本是女性，平均年龄为58.5岁。与正常参与者相比，有大小便失禁症状的参与者报告的症状困扰和HRQL影响显著增加。所有患者组在OAB-Q的所有子量表(p<；0.0001)上均存在显著差异，但睡眠无节制和大小便失禁的影响相似，但显著低于正常参与者(p<；0.0001)。内部一致性较高，各分量表的Cronbachα值在0.86到0.94之间。结论：OAB-Q是区分正常和临床诊断的大小便失禁患者的可靠而有效的工具。OAB-Q表明，失禁和失禁的OAB症状都会引起显著的症状困扰，并对HRQL产生负面影响。
Objective: Overactive bladder (OAB) is characterized by symptoms of urinary frequency and urgency, with and without incontinence, and has been shown to have significant impact on health-related quality of life (HRQL). Currently, no OAB-specific questionnaires exist to evaluate all symptoms of OAB; thus we sought to evaluate the psychometric properties of a newly developed OAB HRQL questionnaire. Methods: The 33-item, self-administered OAB-q contains a symptom bother and HRQL scale. Both the OAB-q and SF-36 were completed by participants from two sources: (1) a community sample who screened positive for OAB in a random-digit dial telephone survey and participated in a clinical validation study (n = 254); and (2) a clinical study of patients' seeking treatment for OAB symptoms (baseline assessment) (n = 736). Item and exploratory factor analysis were performed to assess the subscale structure of the questionnaire. Psychometric evaluation was conducted to assess reliability and validity. Results: Seventy-four percent of the sample were women with mean age of 58.5. Participants with continent and incontinent symptoms reported significantly greater symptom bother and HRQL impact than normal participants. Significant differences were present among all patient groups in all OAB-q subscales (p < 0.0001) except sleep where the impact of continent and incontinent OAB was similar, but significantly worse than normal participants (p < 0.0001). Internal consistency was high with the subscale Cronbach alpha-values ranging from 0.86 to 0.94. Conclusion: The OAB-q is a reliable and valid instrument that discriminates between normal and clinically diagnosed continent and incontinent OAB participants. The OAB-q demonstrates that both continent and incontinent OAB symptoms cause significant symptom bother and have a negative impact on HRQL.