Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy.
Pneumonia, Acute Respiratory Distress Syndrome, and Early Immune-Modulator Therapy.
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DOI：
10.3390/ijms18020388
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发表时间：
2017-02-11
影响因子：
5.6
通讯作者：
Lee KY
中科院分区：
文献类型：
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作者：
Lee KY
急性呼吸窘迫综合征（ARDS）是由感染性损伤引起的，如各种病原体引起的肺炎或与其他非感染性事件有关的肺炎。临床和组织病理学特征在严重受累的患者中相似，提示免疫反应的共同模式可能参与了ARDS的免疫发病机制。在ARDS病例中，可能存在对呼吸细胞具有亲和力并诱导肺细胞损伤的病原物质。这些物质不仅来源于病原体，也来源于受损的宿主细胞。在分子水平上，这些物质具有各种大小和生化特性，将其分为蛋白质物质和非蛋白质物质。免疫细胞和免疫蛋白可以识别并作用于这些物质，包括致病蛋白和肽，这取决于物质的大小和生化特性（该理论被称为蛋白质稳态系统假说）。ARDS的严重程度或慢性程度取决于具有相应免疫反应的病原物质的量、特异性免疫细胞出现的持续时间或控制这些物质的特异性免疫细胞库。因此，尽早使用全身免疫调节剂（皮质类固醇和/或静脉注射免疫球蛋白）治疗可能会减少ARDS潜在阶段的异常免疫反应。
Acute respiratory distress syndrome (ARDS) is caused by infectious insults, such as pneumonia from various pathogens or related to other noninfectious events. Clinical and histopathologic characteristics are similar across severely affected patients, suggesting that a common mode of immune reaction may be involved in the immunopathogenesis of ARDS. There may be etiologic substances that have an affinity for respiratory cells and induce lung cell injury in cases of ARDS. These substances originate not only from pathogens, but also from injured host cells. At the molecular level, these substances have various sizes and biochemical characteristics, classifying them as protein substances and non-protein substances. Immune cells and immune proteins may recognize and act on these substances, including pathogenic proteins and peptides, depending upon the size and biochemical properties of the substances (this theory is known as the protein-homeostasis-system hypothesis). The severity or chronicity of ARDS depends on the amount of etiologic substances with corresponding immune reactions, the duration of the appearance of specific immune cells, or the repertoire of specific immune cells that control the substances. Therefore, treatment with early systemic immune modulators (corticosteroids and/or intravenous immunoglobulin) as soon as possible may reduce aberrant immune responses in the potential stage of ARDS.
DOI：
10.11604/pamj.2014.17.49.3246
发表时间：
2014
期刊：
The Pan African medical journal
影响因子：
--
作者：
Emre JC;Baysak A;Oz AT;Ece G;Arda B;Bacakoglu F
通讯作者：
Bacakoglu F