Exploring consumer exposure pathways and patterns of use for chemicals in the environment
Exploring consumer exposure pathways and patterns of use for chemicals in the environment
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DOI：
10.1016/j.toxrep.2014.12.009
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发表时间：
2015-01-01
影响因子：
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通讯作者：
Judson, Richard S.
中科院分区：
文献类型：
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作者：
Dionisio, Kathie L.;Frame, Alicia M.;Judson, Richard S.
人类在工作场所、家中以及通过空气、水、食物和土壤接触到数千种化学物质。估计化学品暴露的一个主要挑战是了解哪些化学品存在于这些介质和微环境中。在这里，我们描述了化学品/产品类别数据库（CPCat），这是一个新的，公开的（http://actor.epa.gov/cpcat）化学品信息数据库，映射到描述化学品使用或功能的“使用类别”。CPCat是通过结合来自不同国家的监管机构、制造商和零售商的基于消费者和工业过程的化学品使用的多个不同来源的数据而创建的。该数据库使用833个术语的受控词汇表和一种新的命名法来捕获和简化来自各种来源的43,596种化学品的化学用途描述符。提供了CPCat潜在应用的例子，包括确定儿童可能接触到的化学品，并支持对化学品进行毒性筛选的优先次序。CPCat有望成为监管机构、风险评估人员和暴露科学家识别潜在人类暴露源和暴露途径的宝贵资源，特别是用于高通量化学品暴露评估。爱思唯尔爱尔兰有限公司出版。这是一篇基于CC BY-NC-ND许可的开放获取文章
Humans are exposed to thousands of chemicals in the workplace, home, and via air, water, food, and soil. A major challenge in estimating chemical exposures is to understand which chemicals are present in these media and microenvironments. Here we describe the Chemical/Product Categories Database (CPCat), a new, publically available (http://actor.epa.gov/cpcat) database of information on chemicals mapped to "use categories" describing the usage or function of the chemical. CPCat was created by combining multiple and diverse sources of data on consumer-and industrial-process based chemical uses from regulatory agencies, manufacturers, and retailers in various countries. The database uses a controlled vocabulary of 833 terms and a novel nomenclature to capture and streamline descriptors of chemical use for 43,596 chemicals from the various sources. Examples of potential applications of CPCat are provided, including identifying chemicals to which children may be exposed and to support prioritization of chemicals for toxicity screening. CPCat is expected to be a valuable resource for regulators, risk assessors, and exposure scientists to identify potential sources of human exposures and exposure pathways, particularly for use in high-throughput chemical exposure assessment. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license