PARTICIPATION OF PREFRONTAL NEURONS IN THE PREPARATION OF VISUALLY GUIDED EYE-MOVEMENTS IN THE RHESUS-MONKEY
PARTICIPATION OF PREFRONTAL NEURONS IN THE PREPARATION OF VISUALLY GUIDED EYE-MOVEMENTS IN THE RHESUS-MONKEY
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DOI：
10.1152/jn.1989.61.5.1064
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发表时间：
1989-05-01
影响因子：
2.5
通讯作者：
GOLDBERG, ME
中科院分区：
文献类型：
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作者：
BOCH, RA;GOLDBERG, ME
1.我们记录了257个神经元的银行的后三分之一的主要沟的两只恒河猴训练看固定点，使眼跳刺激的视觉周边。66%（220/257）的人在与我们使用的任务的一个或多个方面相关时被释放或抑制。2. 58%（151/257）的神经元对侧视野某部分出现的光点有反应。细胞似乎对刺激的形状、大小或运动方向没有绝对的要求。3. 36%（29/79）的视觉反应神经元的测试定量给予增强的反应，在感受野的刺激时，猴子必须作出眼跳刺激时，其出现与消失的固定点（同步任务）。29%（19/57）的神经元对刺激的反应增强，当猴子在刺激出现一段时间后必须对刺激进行扫视时（延迟扫视任务）。在一般情况下，同步任务的增强与延迟眼跳任务的增强相关。4.增强具有空间特异性。当猴子对感受野外的刺激进行眼跳时，即使感受野内有刺激，也不会发生这种情况。5.在延迟扫视任务中，23%（27/117）的神经元产生了两次爆发，一次是在刺激出现时，另一次是在扫视周围。第二次爆发一般不会发生在猴子对记忆中的目标进行同样的扫视时，而是需要视觉刺激的存在，因此我们将其描述为视觉反应的重新激活。再激活也是空间特异性的。6.从再激活到扫视开始的潜伏期范围从扫视前160 ms到扫视开始。再激活通常在扫视之后持续几百毫秒，有时持续整个试验期间。7.激活和增强不是同一种机制。虽然有些细胞表现出这两种现象，但增强和再激活之间没有相关性。8.在眼跳任务中表现出再激活的细胞在抑制眼跳任务中也表现出较弱水平的再激活。在这项任务中，尽管注视点消失了，周围刺激仍然存在，猴子们还是必须保持注视。（400字处删节）
1. We recorded from 257 neurons in the banks of the posterior third of the principal sulcus of two rhesus monkeys trained to look at a fixation point and make saccades to stimuli in the visual periphery. Sixty-six percent (220/257) discharged or were suppressed in association with one or more aspects of the tasks we used. 2. Fifty-eight percent (151/257) of the neurons responded to the appearance of a spot of light in some part of the contralateral visual field. Cells did not seem to have absolute requirements for stimulus shape, size, or direction of motion. 3. Thirty-six percent (29/79) of visually responsive neurons tested quantitatively gave an enhanced response to the stimulus in the receptive field when the monkey had to make a saccade to the stimulus when its appearance was synchronous with the disappearance of the fixation point (synchron task). Twenty-nine percent (19/57) of the neurons gave an enhanced response to the stimulus when the monkey had to make a saccade to the stimulus some time after it appeared (delayed-saccade task). In general, enhancement in the synchron task correlated well with enhancement in the delayed-saccade task. 4. Enhancement was spatially specific. It did not occur when the monkey made a saccade to a stimulus outside the receptive field even though there was a stimulus within the receptive field. 5. Twenty-three percent (27/117) of neurons studied in the delayed-saccade task gave two bursts, one at the appearance of the stimulus and a second one around the saccade. This second burst generally did not occur when the monkey made the same saccade to a remembered target, but instead required the presence of the visual stimulus, and so we describe it as a reactivation of the visual response. Reactivation was also spatially specific. 6. The latency from reactivation to the beginning of the saccade ranged from 160 ms before the saccade to the beginning of the saccade. Reactivation usually continued for several hundred milliseconds after the saccade, sometimes for the duration of the trial. 7. Reactivation and enhancement are not the same mechanism. Although some cells showed both phenomena there was no correlation between enhancement and reactivation. 8. Cells that showed reactivation in the saccade task also showed reactivation at a weaker level in a suppressed-saccade task. In this task the monkeys had to hold fixation despite the disappearance of the fixation point and the continued presence of the peripheral stimulus.(ABSTRACT TRUNCATED AT 400 WORDS)