Birth weight reduction associated with residence near a hazardous waste landfill.
Birth weight reduction associated with residence near a hazardous waste landfill.
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DOI：
10.1289/ehp.97105856
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发表时间：
1997-08
影响因子：
10.4
通讯作者：
Bove F
中科院分区：
文献类型：
--
作者：
Berry M;Bove F
我们调查了出生体重和母亲居住在危险垃圾填埋场附近的关系。收集了四个城镇25年(1961-1985年)的出生证明。出生被分成五个5年的时期，对应于假设的暴露时期(1971-1975年，接触的可能性最大)。1971年至1975年，与对照人群相比，居住在垃圾填埋场附近(1A区)的父母足月出生(37-44周)的平均出生体重(192克)显著低于对照人群，低出生体重的比例显著高于对照人群[优势比(OR)=5.1；95%可信区间(CI)2.1-12.3]。自1975年后，1A区的平均足月出生体重回升了约332克。在1971-1975年间，在1A区的所有出生婴儿(胎龄和GT；27周)中都发现了类似的结果。在1971-1975年间，与对照组相比，第1A区婴儿早产的风险是对照组的两倍(OR=2.1；95 CI，1.0-4.4)。结果表明，在假定接触风险最大的时期，居住在垃圾填埋场附近的居民所生的婴儿会受到重大影响。这种影响的幅度是在怀孕期间吸烟导致的新生儿体重减轻的范围内。
We examined the relationship between birth weight and mother's residence near a hazardous waste landfill. Twenty-five years of birth certificates (1961-1985) were collected for four towns. Births were grouped into five 5-year periods corresponding to hypothesized exposure periods (1971-1975 having the greatest potential for exposure). From 1971 to 1975, term births (37-44 weeks gestation) to parents living closest to the landfill (Area 1A) had a statistically significant lower average birth weight (192 g) and a statistically significant higher proportion of low birth weight [odds ratio (OR) = 5.1; 95% confidence interval (CI), 2.1-12.3] than the control population. Average term birth weights in Area 1A rebounded by about 332 g after 1975. Parallel results were found for all births (gestational age > 27 weeks) in Area 1A during 1971-1975. Area 1A infants had twice the risk of prematurity (OR = 2.1; 95 CI, 1.0-4.4) during 1971-1975 compared to the control group. The results indicate a significant impact to infants born to residents living near the landfill during the period postulated as having the greatest potential for exposure. The magnitude of the effect is in the range of birth weight reduction due to cigarette smoking during pregnancy.